摘要
Toll样受体（TLR）是一类模式识别受体，在多种细胞中表达，在固有免疫和后续的获得性免疫中发挥重要作用。同时它也参与了机体细胞的免疫、增殖、凋亡等生理进程。TLR在血液恶性肿瘤中有表达，并与肿瘤的发生发展、免疫逃逸、耐药密切相关，发挥了双刃剑的作用。文章主要对TLR分子的基本知识和在血液肿瘤方面的研究进行综述，为血液恶性肿瘤的治疗提供思路。
The Toll-like receptors are a kind of pattern recognition receptors, which are expressed in a variety of cells, playing an important role in innate immunity and subsequent acquired immunity. At the same time, they are also involved in the immunity, proliferation, apoptosis and other physiological processes of the cells. Toll-like receptors are also expressed in hematological malignancies and involved in the progress of tumor development, immune escape, resistance, which play a double-edged sword role. In this paper, basic knowledge of TLR molecule and study on hematological tumor were mainly reviewed, aiming to provide a train of thoughts for the treatment of hematologic malignancies.
出处
《肿瘤研究与临床》
CAS
2015年第11期788-790,共3页
Cancer Research and Clinic
