摘要
目的探讨CA125、CA153、HE4联合检测在妇科恶性肿瘤诊断中的临床价值。方法选择2013年在我院治疗的妇科恶性肿瘤患者70例,设立同期确诊的良性妇科疾病患者72例,健康对照70例,检测CA125、CA153、HE4表达水平,进行统计学分析。结果在恶性肿瘤组与良性疾病组比较中,单项检测CA125阳性率、单项检测HE4阳性率、联合检测CA125、CA153、HE4阳性率有统计学差异(前者p<0.05,后两者p<0.01),联合检测阳性率最高达72.9%。结论 HE4是妇科恶性肿瘤诊断灵敏度和特异度都最高的单一肿瘤标志物,联合检测CA125、CA153、HE4提高对妇科恶性肿瘤诊断的阳性率。
Objective To investigate the clinical value of CA125,CA153,HE4 joint detection in diagnosis of gynecological malignancies. Methods 70 cases of gynecological malignancies were selected from our hospital in2013,72 cases of benign gynecological diseases selected in the same period,and 70 healthy controls were selected.The expression levels of CA125,CA153 and HE4 were detected and statistically analyzed. Results The positive rate of serum CA125 in the gynecological malignancies group was higher than that in the benign gynecological disease group（ p〈0. 05）. The positive rate of serum HE4 in the gynecological malignancies group was higher than that in the benign gynecological disease group（ p〈0. 01）. The positive rate of CA125,CA153,HE4 joint detection in the gynecological malignancies group（ up to 72. 9%） was also significantly higher than that in the benign gynecological disease group（ p〈0. 01）. Conclusion is a single tumor marker with the highest sensitivity and specificity for diagnosis of gynecological malignancies. CA125,CA153,HE4 joint detection can improve the positive rate of diagnosis of gynecological malignancies.
出处
《现代医院》
2015年第1期69-70,74,共3页
Modern Hospitals
