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CEA、CA125和CA153与乳腺癌病理特征的关系及其术后化疗动态监测的意义 被引量:6

THE RELATIONSHIP BETWEEN CEA/CA125/CA153 AND THE PATHOLOGICAL CHARACTERISTICS OF BREAST CANCER AND THE SIGNIFICANCE OF DYNAMIC MONITORING OF CHEMOTHERAPY
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摘要 目的 探讨CA153、CA125和CEA与乳腺癌病理的关系及术后化疗动态监测的意义。方法选取107例手术并经过化疗的乳腺癌患者,分别于术前、术后1个月、术后2个月检测CA153、CA125和CEA水平。结果 CA153、CA125和CEA阳性率与其ER、PR、p53病理结果差异无统计学意义(P〉0.05)。TNMⅢ~Ⅳ期乳腺癌组CA153阳性率较TNM I~Ⅱ期乳腺癌组高,差异有统计学意义(P〈0.05)。淋巴结转移组CA153和CEA阳性率较非淋巴结转移组高,差异有统计学意义(P〈0.05)。在复发转移组术前和术后第2个月CA153水平高于非复发转移组,差异有统计学意义(P〈0.05)。结论 CA153、CA125和CEA动态监测是监控乳腺癌复发与转移较好的预警指标,且CA153的价值优于CA125和CEA。 Objective To explore the relationship between CA153/CA125/CEA and the pathological characteristics of breast cancer and the significance of dynamic monitoring of postoperative chemotherapy. Method 107 patients with breast cancer after surgery and chemotherapy were collected and CA153/CA125/CEA was detected before operation, 1 month and 2 month ofpost - operation respectively. Result The positive rates of CA153, CA125 and CEA bad no relation with ER, PR, and p53 (P 〉0. 05). The positive rates of CA153 in TNM Ⅲ- Ⅳ group was higher than that in TNM Ⅰ - Ⅱ group( P 〈 0.05 ). The positive rate of CEA and CA153 in lymph node metastasis group was higher than that in non -lymph node metastasis group (P 〈 0. 05 ). The level of CA153 in patients with recurrence and metastasis group was higher than that in non - recurrence group before operation and 2 months after operation ( P 〈 0. 05 ). Conclusion The dynamic detection of CA153, CA125 and CEA are better early warning indicators for monitoring recurrence and metastasis of breast cancer. And the value of CA153 is better than CA125 and CEA.
出处 《现代医院》 2015年第12期53-55,58,共4页 Modern Hospitals
关键词 乳腺癌 糖类抗原153 糖类抗原125 癌胚抗原 病理 复发 Breast cancer CA153 CA125 CEA Pathology Recurrence
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