摘要
目的探讨降钙素原(PCT)在急性胆道系统感染围手术期抗感染疗效中的临床评价,为感染控制的判断提供依据。方法选取2011年1月-2014年1月100例行手术治疗的急性胆道系统感染住院患者,将其按照随机数表法分为观察组和对照组,每组各50例,两组患者在围手术期均采取抗菌药物治疗,入院后隔日抽取两组患者静脉血,检测血清中PCT及血常规指标水平。结果两组患者的抗菌药物应用分别为(6.2±2.4)(4.1±2.0)d,观察组患者的抗菌药物应用天数明显少于对照组(P<0.05);随着治疗时间的推移,两组患者的血清PCT水平均呈不断降低的趋势,且明显低于治疗前,治疗后不同时间点比较差异有统计学意义(P<0.05);观察组患者治疗后第1、3、5天的血清PCT水平稍低于对照组,比较差异无统计学意义;重症和非重症患者治疗后不同时间点的PCT水平均明显低于治疗前(P<0.05),呈不断下降的趋势,且重症患者不同时间点的PCT水平均明显高于非重症患者(P<0.05);经Person相关性分析发现,PCT含量变化与疾病严重程度呈正相关(r=0.81,P<0.05)。结论 PCT水平的监测在急性胆道系统感染围手术期抗感染治疗中具有很好的指导作用,可有效反应病情的严重程度及变化,并能动态监测抗感染治疗的疗效。
OBJECTIVE To evaluate the clinical efficacy of procalcitonin （PCT ） in treatment of perioperative acute biliary tract infection so as to provide guidance for control of the infection .METHODS A total of 100 patients with acute biliary tract infection who receive surgical procedures from Jan 2011 to Jan 2014 were enrolled in the study and randomly divided into the observation group and the control group ,with 50 cases in each group .The two groups patients were treated with antibiotics during the perioperative period ,and the venous blood was extracted every other day after the admission for the detection of levels of serum PCT and blood routine indicators .RESULTS The duration of use of antibiotics of the observation group was （4 .1 ± 2 .0）d ,significantly shorter than （6 .2 ± 2 .4）days of the control group （P〈0 .05） .The serum PCT level of the two groups of patients showed a downward trend with the time of treatment and was significantly lower than that before the treatment ,and there was signifi‐cant difference among the different time points after the treatment （P〈0 .05） .The levels of serum PCT of the ob‐servation group were a bit lower than those of the control group on Day 1 ,3 ,and 5 after the treatment ,and there was no significant difference .The levels of PCT of the critically ill patients and the non‐critically ill patients were significantly lower at the different time points after the treatment than before the treatment （P〈0 .05） ,showing downward trends ,and the levels of PCT of the critically patients were significantly higher than those of the non‐critically ill patients at the different time points （P〈 0 .05） .The Person correlation analysis showed that the change of PCT level was positively correlated with the severity of disease （r=0 .81 ,P〈0 .05） .CONCLUSION The surveillance of the PCT level plays an important role in guiding the treatment of perioperative acute biliary tract in‐fection ,and it can effectively reflect the severity of illnes
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第22期5149-5151,共3页
Chinese Journal of Nosocomiology
基金
浙江省卫生厅基金资助项目(2013KYB294)
关键词
急性胆道系统感染
围手术期
降钙素原
抗菌药物
Acute biliary tract infection
Perioperative period
Procalcitonin
Antibiotic
