摘要
干粉吸入剂(DPI)是最具发展潜力的肺部给药制剂,临床上被广泛用于肺部局部疾病的治疗,还为某些作用于全身的药物提供了新的给药途径。DPI肺部给药过程直接决定DPI的临床疗效,该过程包括干粉的分散、雾化和肺部沉积,其受多因素共同影响,主要包括干粉的粉体学性质、给药装置和吸入气流速率三方面。临床应用中,需要平衡各影响因素,以实现药物最大的分散、雾化和肺部沉积。本文对DPI肺部给药过程的影响因素及研究进展进行综述。
As the most promising preparation for pulmonary administration,dry powder inhaler（ DPI） is widely employed to deliver drugs to the respiratory epithelium,predominantly for the treatments of local disorders recently. This delivery system has also become an attractively non-invasive way for systemic administration of the biologically active components. In addition,the clinical efficacy of DPIs depends on the pulmonary drug delivery process,which involves powder dispersion,aerosolization and lung deposition. However,the process is influenced by a variety of factors,especially particles engineering,drug inhaler devices and inspiration flow rate. Thus,it is indispensable to balance the various factors in order to achieve maximum dispersion,aerosolization and lung deposition of the drug in the clinical application. The focus of this article is exclusively on the latest progress in the factors impacting the pulmonary drug delivery process of DPIs,to provide a reference for the development of the delivery of fine drug particles to the bottom of the lung.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2015年第21期2459-2466,共8页
Chinese Journal of New Drugs
基金
国家“重大新药创制”科技重大专项(2014ZX09507005-001)
关键词
干粉吸入剂
肺部给药
肺部沉积
粉体学性质
给药装置
吸入气流速率
dry powder inhaler
pulmonary administration
pulmonary deposition
particles engineering
inhaler drug device
inspiration flow rate
