摘要
肺部给药是一种简单、直接、有效、无侵害性的给药方式,肺部药物递送可以达到局部及全身的治疗效果。纳米给药系统具有靶向及缓释特性,在提高治疗指数、降低不良反应方面具有显著优势。通过将纳米粒溶液或纳米粒和辅料的混合液进行喷雾干燥,可制得中空性纳米聚集颗粒。中空性纳米聚集颗粒具有较大几何直径和较小的密度,能够提高粒子的空气动力学直径,得到良好的肺部沉积率,是一种潜在的肺部纳米给药系统新剂型。本文从中空性纳米聚集颗粒的形成原理、影响因素、制备工艺等方面阐述了该新型制剂的关键技术,并对其物理化学性质、粉体动力学性质以及用于肺部给药的评价指标进行了总结,为该种新剂型应用于肺部给药的干粉吸入剂提供了制剂学参考。
Pulmonary drug delivery system has the advantages such as convenience to dose,rapid onset of action,effective and non-invasive nature,which can be used for both topical and system therapy. Nanoparticlesbased drug delivery system characterized with sustained and controlled release properties have shown significant advantages in improving therapeutic index and reducing adverse reactions. Large hollowed nanoparticulate aggregates（ LHNAs） can be manufactured via a spray drying process of nanoparticulate suspensions or nanosuspension mixed with excipients. LHNAs owning larger geometric size and smaller density,which provide a suitable aerodynamic diameter for a higher pulmonary deposition ratio,is a promising nano-drug delivery system for pulmonary delivery.This article gives an overview of the formation mechanism,influence factors,preparation techniques,and property evaluation of LHNAs and summarizes its physicochemical property,powder property and evaluation indicators for pulmonary delivery,aiming to provide a reference for its application as dry powder inhalation for pulmonary delivery from the point of pharmaceutics.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2016年第13期1489-1495,共7页
Chinese Journal of New Drugs
关键词
中空性纳米聚集颗粒
肺部给药
制备
性质
large hollowed nanoparticulate aggregates
pulmonary delivery
preparation
property
