摘要
目的探讨血清超敏C反应蛋白（hs-CRP）水平与急性冠脉综合征（ACS）危险分层的相关性。方法选取2014年6月至2015年6月军事医学科学院附属医院收治的ACS患者。入院后测定血清hs-CRP水平,采用GRACE评分对ACS进行危险分层,分析两者间的相关性,评估hs-CRP预测ACS高危患者的敏感性与特异性。结果共入组112例ACS患者。入组患者血清hs-CRP水平与GRACE危险评分呈正相关（r=0.519,P〈0.001）。根据ROC曲线结果,hs-CRP诊断ACS高危患者的AUC为0.789（95%CI：0.701~0.878,P〈0.001）。设血清hs-CRP水平为3.5mg/L为预测ACS患者GRACE高危组的临界点,其诊断ACS高危患者的敏感性和特异性分别为81.0%、58.4%。结论本研究结果证实入院早期的血清hs-CRP水平与GRACE评分呈显著的相关性,其可以有效反映ACS患者的危险程度。
Objective To investigate the relationship between high-sensitivity C-reactive protein levels and risk stratification of acute coronary syndrome. Methods 112 patients with acute coronary syndrome （ACS）treated in the affiliated hospital of academy of military medical sciences were involved in this study. The high-sensitivity C-reactive protein levels （hs-CRP ） in patients were detected. The GRACE score was used for ACS risk stratification and relationship between them was analyzed. Results The serum hs-CRP levels was positively correlated with GRACE risk score（r =0.519, P 〈0.001 ）. According to the ROC curve, the AUC of hs-CRP to diagnosis high-risk patients was 0. 789 （95 % CI： O. 701-0878, P 〈 O. 001 ）. The sensitivity and specificity for high risk diagnosis of ACS patients were 81.0% and 58.4% respectively. Conclusion There is a significant correlation between the serum hs-CRP and GRACE score at the earlier stage of ACS patients admission. The high-sensitivity C-reactive protein levels can effectively reflect the degree of the risk of ACS patients.
出处
《标记免疫分析与临床》
CAS
2015年第10期956-959,共4页
Labeled Immunoassays and Clinical Medicine
