摘要
目的探讨急性AMI(AMI)患者血清超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP9)、可溶性趋化因子-16(soL-CXCL16)、N-末端脑钠肽前体(NT-proBNP)的变化及其意义。方法选取我院(2016.01~2017.01)收治的140例AMI患者(AMI组)、健康体检对象70例(对照组),检测两组对象的血清hs-CRP、MMP9、soL-CXCL16、NT-proBNP水平,并根据冠脉病变支数、PCI治疗前后进行组内分层分析。结果AMI组患者的hs-CRP、MMP9、soL-CXCL16、NT-proBNP水平均显著的高于对照组,差异有统计学意义(P<0.05);三支病变的AMI组患者的血清hs-CRP、MMP9、soL-CXCL16、NT-proBNP水平均显著的高于单支病变组和双支病变组,差异有统计学意义(P<0.05);双支病变患者的血清hs-CRP、MMP9、soL-CXCL16显著高于单支患者,差异有统计学意义(P<0.05);PCI治疗后3天,AMI组患者的血清hs-CRP、MMP9、soL-CXCL16、NT-proBNP水平较术前进一步升高,差异有统计学意义(P<0.05);PCI术后第7天,AMI患者血清hs-CRP、MMP9、soL-CXCL16、NT-proBNP水平均较术前降低,差异有统计学意义(P<0.05)。结论AMI患者hs-CRP、MMP9、soL-CXCL16、NT-proBNP水平较健康人群升高,对于评估病情及PCI手术效果具有一定的临床价值。
Objective To investigate the change and significance of serumhigh-sensitivity C-reactive protein(hs-CRP)、matrix metalloproteinase-9(MMP9),soluble chemokine-16(soL-CXCL16)and N-terminal pro-Brain natriuretic peptide(NT-proBNP)levels in patients with acute myocardial infarction(AMI). Methods A total of 140 patients with AMI(AMI group)and 70 healthy subjects(control group)administrated in our hospital between January 2016 and January 2017 were enrolled.Serum levels of hs-CRP,MMP9,soL-CXCL16 and NT-proBNPwere measured in the two groups.Further analysis stratified by the number of diseased coronary vessels,pre-and post-treatment of percutaneous coronary intervention(PCI)wasperformedwithin groups. Results The levels of hs-CRP,MMP9,soL-CXCL16 and NT-proBNPof AMI patients were significantly higher than those in the control group( P <0.05).In the AMI group,stratification analysis showed that the levels of hs-CRP,MMP9,soL-CXCL16 and NT-proBNP in patients with three diseased coronary vessels were significantly higher than those with one or two diseased coronary vessels( P <0.05).And those with two diseased coronary vessels had higher serum hs-CRP、MMP9、soL-CXCL16concentration than those with single diseased coronary vessel( P <0.05).Serum levels of hs-CRP、MMP9、soL-CXCL16、NT-proBNP in AMI patients were increased on the third day( P <0.05)and decreased on the seventh day( P <0.05)after PCI treatment compared with the pre-treatment data. Conclusion Serum levels of hs-CRP,MMP9,soL-CXCL16 and NT-proBNP in patients with AMI were significantly higher than those in healthy people,which has certain clinical value for the evaluation of disease severity and the efficacy assessment of PCI therapy.
作者
刘家超
张巧玲
陈虹
杨文强
杨溶海
梁建光
雷志红
曾小茹
Liu Jiachao;Zhang Qiaoling;Chen Hong(Department of Cardiovascular Medicine,Foshan Sanshui District People′s Hospital,Clinical Laboratory,Foshan Sanshui District People′s Hospital,Foshan,Guangdong 528100,China)
出处
《四川医学》
CAS
2019年第6期593-596,共4页
Sichuan Medical Journal
基金
佛山市医学类科技攻关项目(编号:2016AB001415)
