摘要
目的分析新生儿高胆红素血症行换血治疗的效果以及治疗后的不良反应。方法回顾性分析262例采用换血治疗的高胆红素血症新生儿的临床资料,比较治疗前后血电解质、血生化、血气分析以及血常规结果,并观察治疗后不良反应发生情况。结果患者治疗前后的血钾、剩余碱(BE)值、p H值、血小板、血红蛋白、间接胆红素、血清总胆红素等指标相比差异明显,有统计学意义(P<0.05);患者治疗前后的直接胆红素、白细胞、血钠、血氯以及血钙等指标相比差异不显著,无统计学意义(P>0.05)。患者治疗后的不良反应主要有代谢性酸中毒、低钾血症以及血小板减少,通过对其进行适当处理后均恢复正常。结论在对高胆红素血症新生儿进行临床治疗时,换血治疗可以有效改善患者的相关临床症状,不过在治疗过程中一定要对患者的换血适应症以及相关指征进行严格控制,并对患者在治疗后的不良反应进行积极处理。
Objective To study the effects and adverse reactions of exchange transfusion in treating neonatal hyperbilirubinemia. Methods Clinical data of 262 newborns with hyperbilirubinemia received exchange transfusion were retrospectively analyzed. The results of blood electrolytes, blood biochemical test, blood gas analysis and blood routine examination before and after the treatment were compared, and the incidence of adverse reactions was observed. Results The blood potassium, base excess value, pH value, blood platelet, hemoglobin, indirect bilirubin, serum total bilirubin before and after treatment had statistical difference （P〈0.05）, the direct bilirubin, leukocyte, serum sodium, serum chloride, serum calcium before and after treatment had no statistical difference （P 〉0.05）. The main adverse reactions of patients were metabolic acidosis, hypokalemia and thrombocytopenia, all patients returned to normal after giving proper treatment. Conclusions In clinical treatment of neonatal hyperbilirubinemia, exchange transfusion can effectively improve the patient＇s clinical symptoms, but the relevant indications must be strictly controlled, and the adverse reactions should be given positive treatment.
出处
《临床医学工程》
2015年第10期1323-1324,共2页
Clinical Medicine & Engineering
关键词
新生儿
高胆红素血症
不良反应
换血治疗
Newborn
Hyperbilirubinemia
Adverse reaction
Exchange transfusion
