摘要
目的通过检测Survivin和P53在乳腺癌组织及正常乳腺组织中的表达情况,从而探讨两者与乳腺癌发生发展的关系。方法采用免疫组化SP方法检测乳腺癌组织及正常乳腺组织中Survivin和P53的表达情况,比较Survivin和P53在两种不同组织中的表达情况。结果乳腺癌组织中,Survivin的表达阳性率为76.0%(38/50),在正常乳腺组织中Survivin的表达阳性率为10.0%(2/20),Survivin在乳腺癌组织表达阳性率高于正常乳腺组织,差异有显著性(P<0.05)。P53在乳腺癌组织中的表达阳性率为78.0%(39/50),在正常乳腺中的阳性表达率为15.0%(3/20),P53在乳腺癌组织表达阳性率高于正常乳腺组织,差异有显著性(P<0.05)。Survivin的表达水平与乳腺癌分化程度、浸润深度、淋巴结转移无明显相关;但是P53与乳腺癌分化程度、淋巴结转移明显相关。结论 Survivin与P53与乳腺癌的发生及发展密切相关,检测Survivin与P53的表达水平可以作为辅助诊断乳腺癌的标准,同时检测P53的表达水平可以预测乳腺癌患者预后情况。
Objective By detecting Survivin and P53 in breast cancer and normal breast tissues,and thereby to explore the relationship between the occurrence of breast cancer development. Methods SP immunohistochemical method to detect cases by comparing their expression in breast cancer tissue and normal breast tissue expression both in two different tissues. Results Survivin expression positive rate in breast cancer was 76. 0%(38/50). Survivin expression positive rate in normal breast tissue was 10. 0%(2/20). The positive rate of Survivin expression in breast cancer was higher than in normal breast tissue. There was significantly difference( P <0. 05). The positive rate of P53 expression in breast cancer was 78. 0%(39/50),the positive rate of P53 expression in normal gastric mucosa was 15. 0%(3/20). The positive rate of P53 expres-sion in breast cancer was higher than in normal breast tissue. There was significantly difference( P <0. 05). Survivin expression levels with the degree of differentiation of in breast cancer,lymph node metastasis was no significant correlation;but P53 degree of differentiation of breast canc-er,depth of invasion,lymph node metastasis was significantly correlated. Conclusion Survivin and P53 was closely related to the occurrence and development of breast cancer. By detecting the expression level of Survivin and P53 can be used as a standard diagnosis of breast cancer. Detecting the expression level of P53 can predict the prognosis of breast cancer patients.
出处
《临床和实验医学杂志》
2015年第17期1446-1448,共3页
Journal of Clinical and Experimental Medicine
