摘要
目的:探讨抑癌基因Survivin、p53、p21在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法:采用免疫组织化学S-P法检测50例NSCLC组织及15例肺非癌组织中的Survivin、p53、p21蛋白的表达情况。结果:Survivin、p53、p21在NSCLC组织中的表达水平明显高于肺良性病变及癌旁组织;Survivin、p53、p21表达和TNM分期、淋巴结转移有关,而与不同的病理类型、性别无关。结论:Survivin、p53、p21与NSCLC的发生、发展有密切关系,与NSCLC的生长、浸润和转移有关;Sur-vivin、p53、p21可作为NSCLC的预后指标。
Objective ：To detect the expression levels of survivin and p53 and p21 and their clinical significance in the non- small cell lung cancer tissues. Methods：S-P immunohistochemistry was used to analyze the protein expressions of survivin, p53 and p21 from 50 well-characterized non-small cell lung cancer patients and 15 lung negative tissues and para-cancerous tissues. Results： Positive expressions of survivin, p53 and p21 were significantly higher organized in the tissues of non-small cell lung cancer than in the lung negative tissues and para-cancerous tissues. Positive exspressions of survivin, p53 and p21 were associated with the tumor node metastasis staging system of lung cancer and lymph node metastasis, were not associated with the types and gender in the expression of the different lung cancer pathology. Conclusion：Survivin, p53 and p21 were highly associated with the occurrence and development of the non-small cell lung cancer. Survivin, p53 and p21 have relations with the growth,invasion and metastasis of the non-small cell lung cancer. The expressions of these proteins are the predictors for prognostic factors of non-small cell lung cancer.
出处
《临床肿瘤学杂志》
CAS
2008年第9期788-791,共4页
Chinese Clinical Oncology
