摘要
目的：为探索增殖细胞核抗原（ＰＣＮＡ）和ｐ２１在喉非典型增生与其转化后的鳞癌中的表达有无差异。方法：用ＡＢＣ免疫组化技术对３７例分别来自同一患者的喉非典型增生和鳞癌及７例正常喉组织进行了ＰＣＮＡ、ｐ２１检测。结果：ＰＣＮＡ和ｐ２１的表达在喉癌与非典型增生间均有统计学差异；由非典型增生至癌，其ＰＣＮＡ指数升高的有３０对；正常喉组织的ＰＣＮＡ指数显著低于喉病变组织，ｐ２１染色阴性。结论：ｐ２１的过度表达与喉非典型增生和喉癌的发生有关。
Objective:To find out whether the expression of PCNA and p21 in laryngeal dysplasia is diffarent or not from that in laryngeal cancer transformed from it.Methods:The avidin biotin peroxidase method was used to detect PCNA and p21 in 37 pairs of samples of laryngeal dysplasia and squamous cell carcinoma of larynx [each pair of samples were collected from the same patient]and 7 samples of normal tissues of larynx.Results:Significant difference in expression of p21 and PCNA existed between the dysplasia and the cancer.The PCNA indices increased in 30 cases who began with dysplasia and later developed cancer.The positive rate stained for p21 was zero and PCNA index was very low in normal tissues.Conclusion:Overexpression of p21 is related to the development of dysplasia and cancer in larynx.High PCNA index is helpful to the diagnosis and differential diagnosis of laryngeal cancer.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
1998年第3期148-150,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
增殖细胞核抗原
P21
喉肿瘤
非典型增生
鳞癌
Proliferating cell nuclear antigen(PCNA) p21 Laryngeal neoplasms Carcinoma,squamous cell Dysplasia
