摘要
目的探讨血清降钙素原(PCT)、C-反应蛋白(hs-CRP)及白细胞介素-6(IL-6)在重症肺炎患者中的含量变化及临床诊断意义。方法选取2014年1月至2015年1月于我院诊治的重症肺炎患者80例,以28 d为观察期,患者分为存活组41例和死亡组39例。检测两组患者血清中PCT、hsCRP及IL-6水平,并行比较。结果死亡组PCT水平逐渐上升(P<0.05);存活组PCT水平逐渐下降(P<0.05);死亡组PCT水平显著高于存活组(P<0.05)。死亡组hs-CRP水平逐渐上升(P<0.05);存活组hs-CRP水平逐渐下降(P<0.05);死亡组hs-CRP水平显著高于存活组(P<0.05)。死亡组IL-6水平逐渐上升(P<0.05);存活组IL-6水平逐渐下降(P<0.05);死亡组IL-6水平显著高于存活组(P<0.05)。结论 PCT、hs-CRP及IL-6与重症肺炎患者疾病严重程度具有一定相关性,可作为临床诊治的指标。
Objective To investigate level changes of Serum procalcitonin,C- reactive protein,interleukin- 6 in patients with severe pneumonia,and its clinical diagnostic significance. Methods 80 cases of patients with severe pneumonia in our hospital from January 2014 to January 2015 were selected,and they were divided into survival group（ 41） and death group（ 39） based on 28 days observation period. The serum PCT,hs- CRP and IL- 6 levels of two groups were detected and compared. Results The PCT level of death group was gradually decreased（ P〈0. 05）. The PCT level of survival group was gradually increased（ P〈0. 05）. The PCT level of death group was significantly higher than the survival group（ P〈0. 05）. The hs- CRP level of death group was gradually decreased（ P〈0. 05）. The hs- CRP level of survival group was gradually increased（ P〈0.05）. The hs- CRP level of death group was significantly higher than the survival group（ P〈0. 05）. The IL- 6level of death group was gradually decreased（ P〈0. 05）. The IL- 6 level of survival group was gradually increased（ P〈0. 05）. The IL- 6 level of death group was significantly higher than the survival group（ P〈0.05）. Conclusions PCT,hs- CRP and IL- 6 levels were related to disease severity of patients with severe pneumonia,they can be used as diagnosis and treatment indicators.
出处
《齐齐哈尔医学院学报》
2015年第23期3439-3441,共3页
Journal of Qiqihar Medical University
关键词
血清降钙素原
C反应蛋白
白介素-6
重症肺炎患者
Serum procalcitonin
C-reactive protein
Interleukin-6
Patients with severe pneumonia
