摘要
目的:探讨阿托伐他汀对原发性高血压患者血压、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)的影响。方法:将76例患者随机分为对照组(39例)和阿托伐他汀组(37例),对照组接受硝苯地平、氢氯噻嗪等常规抗高血压治疗,阿托伐他汀组在常规治疗的基础上加用阿托伐他汀,观察期为10周,分别于治疗前后测定两组患者的血压、CRP和TNF-α水平,并进行统计学分析。结果:阿托伐他汀组的血压、CRP和TNF-α水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:阿托伐他汀能够进一步改善高血压患者的血压,且具有抗炎的效果。
Objective：To investigate effect of atorvastatin on blood pressure,C-reactive protein（CRP） and tumor necrosis factor-α（TNF-α） in patients with essential hypertension.Method：76 patients wiht hypertension were randomly divided into control group（n=39）and atorvastatin group（n=37）.Control group were administrated hydrochlorothiazide,nifedipine and atorvastatin group received atorvastatin in addition everyday for 10 weeks.Change of blood pressure,CRP and TNF-α in serum of subjects were measured before and after 10-weeks.Date were analysed with statistical methods.Result：After 10 weeks,BP,content of CRP and TNF-α were significantly lower in atorvastatin group than in control group.Conclusion：Atorvastatin may dicrease blood pressure and improve vascular function in patients with Essential Hypertension.
出处
《中国医学创新》
CAS
2012年第20期24-25,共2页
Medical Innovation of China
关键词
高血压
阿托伐他汀
C反应蛋白
肿瘤坏死因子-Α
Hypertension
Atorvastatin
C-reactive protein（CRP）
Tumor necrosis factor-α（TNF-α）
