摘要
目的：分析糖尿病肾脏疾病患者血清中蛋白激酶C-η（protein kinase C-η,PKC-η）、蛋白激酶C-ζ（protein kinase C-ζ,PKC-ζ）、血脂和炎性因子的表达情况以及 PKC-η、PKC-ζ与血脂和炎性因子的相关性。方法选择2010年6月到2014年6月黄石市中心医院肾内科收治的糖尿病肾脏疾病患者18例（观察组）；另选择健康体检人员20名为对照组。比较2组 PKC-η、PKC-ζ、血脂及炎性因子含量,并运用Pearson相关分析其相关性。结果观察组血尿素氮（BUN）、血肌酐（SCr）、血尿素、血尿酸、血总胆固醇（total cholesterol,TC）、三酰甘油（trilaurate glycerin,TG）、低密度脂蛋白胆固醇（low densith lipoprotein-cholesterol,LDL-C）、白细胞介素1α（inter leukin-1α,IL-1α）、白细胞介素1β（interleukin-1β,IL-1β）、白细胞介素6（interleukin-6,IL-6）以及肿瘤坏死因子α（tumor necrosis factor-α,TNF-α）明显高于对照组,差异有统计学意义（P〈0.05）；观察组内生肌酐清除率（creatinine clear-ance rate,Ccr）和高密度脂蛋白胆固醇（high density lipoprotein-cholesterol,HDL-C）明显低于对照组,差异有统计学意义（P〈0.05）；观察组 PKC-η和 PKC-ζ明显高于对照组,差异有统计学意义（P〈0.05）。PKC-η、PKC-ζ分别与4个炎性因子相关性分析显示,PKC-η与 IL-1α、IL-1β、IL-6及 TNF-α成正相关（r=0.562、0.518、0.754、0.634,P〈0.05）；PKC-ζ与 IL-1α、IL-1β、IL-6及 TNF-α成正相关（r=0.551、0.576、0.733、0.584,P〈0.05）。PKC-η、PKC-ζ分别与血脂相关性分析显示,PKC-η与TC、TG、LDL-C 成正相关（r=0.566、0.538、0.604,P〈0.05）,PKC-η与 HDL-C 成负相关（r=-0.732,P〈0.05）；PKC-ζ与TC、TG、LDL-C 成正相关（r=0.577、0.565、0.544,P〈0.05）；PKC-ζ与 HDL-C成负相关（r=-0.721,P〈0.05）。结论糖尿病肾脏疾病患者全血中 PKC-η和 PKC-ζ浓度明显升高,同时其与血脂（TC、TG、LDL-C 和 HDL-C）及炎�
Objective To analyze and discuss the correlation between the protein kinase C-η（PKC-η）,protein kinase C-ζ（PKC-ζ）with blood lipids,inflammatory factors in patients with diabetic kidney disease （DKD）.Methods Eighteen cases of DKD （observation group）treated in Huangshi Central Hospital from June 2010 to June 2014 and 20 cases of healthy volunteers （control group）were collected.PKC-η,PKC-ζ,blood lipids,and inflammatory factors were compared,and the correlation was analyzed by Pearson correlation analysis.Results The values of blood urea nitrogen （BUN）,ser-um creatinine （SCr）,blood urea,blood uric acid,total cholesterol （TC）,trilaurate glycerin （TG）, low density lipoprotein-cholesterol （LDL-C）,interleukin-1α（IL-1α）,IL-1β,IL-6 and tumor necrosis factor-α（TNF-α）in observation group were significantly higher than those in control group （P〈0.05）.The levels of creatinine clearance,and HDL-C in observation group were significantly lower＆amp;nbsp;than those in control group （P〈0.05）.The levels of PKC-ηand PKC-ζin observation group were ob-viously higher than those in control group （P〈0.05）.The correlation analysis revealed that PKC-ηwas positively correlated with IL-1α,IL-1β,IL-6 and TNF-α（r=0.562,0.518,0.754 and 0.634 re-spectively,P〈0.05 ）;PKC-ζwas positively correlated with IL-1α,IL-1β,IL-6 and TNF-α（r=0.551,0.576,0.733 and 0.584 respectively,P〈0.05）.PKC-ηwas positively correlated with TC, TG and LDL-C （r=0.566,0.538,and 0.604 respectively,P〈0.05）.PKC-ηwas negatively correla-ted with HDL-C （r=-0.732,P〈0.05）.PKC-ζwas positively correlated with TC,TG and LDL-C （r=0.577,0.565 and 0.544 respectively,P〈0.05）.PKC-ζwas negatively correlated with HDL-C （r=-0.721,P〈0.05）.Conclusions PKC-ηand PKC-ζin patients with DKD were significantly in-creased,meanwhile they show obvious correlation with serum lipids （TC,TG,LDL-C,and HDL-C） and inflammatory factors （IL-1α,IL-1β,IL-6,and TNF-α）.
出处
《临床肾脏病杂志》
2015年第7期422-426,共5页
Journal Of Clinical Nephrology
基金
湖北省科技厅资助(NO.2012FFA016)
