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血脂水平对胰岛功能的影响在2型糖尿病和正常人群中存在差异 被引量:8

Different effects of lipid components on insulin secretion in patients with type 2 diabetes and subjects with normal glucose metabolism
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摘要 研究血脂对胰岛功能的影响在2型糖尿病及正常人群中是否表现不同。结果表明,在正常人群中,处置指数(DI)0与高密度脂蛋白胆固醇(HDL—C)呈正相关,D130与总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL—C)呈负相关,DI120与TC、LDL—C呈负相关;在2型糖尿病中,D10与TC、LDL—C呈负相关,D130与TC、TG、LDL—C、TG/HDL—C呈负相关,DI120与TC、TG、LDL—C、TG/HDL—C呈负相关。 The effects of lipid components on insulin secretion in patients with type 2 diabetes ( T2DM ) and control subjects were explored. The results demonstrated that in control group, disposal index ( DI )0 was positively correlated with high density cholesterol ( HDL-C ), while DI30 was negatively correlated with total cholesterol ( TC ), triglycerides(TG) and low density cholesterol (LDL-C), and DI120 was also negatively correlated with TC and LDL-C. In T2DM group, DIO was negatively correlated with TC and LDL-C, DI30 was negatively correlated with TC, TG, LDL-C and TG/HDL-C, DI120 was negatively correlated with TC, TG, LDL-C and TG/HDL-C.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2015年第7期599-600,共2页 Chinese Journal of Endocrinology and Metabolism
基金 南京市卫生局基金项目(YKK13195)
关键词 胰岛Β细胞功能 血脂 糖尿病 2型 Pancreatic β cell function Blood lipid Diabetes mellitus, type 2
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  • 1Bi Y, Zeng L, Zhu D, et al. Association of beta-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population[ J]. Diabetes Obes Metab, 2012,14 (2) : 174-180. 被引量:1
  • 2Abderrahmani A, Niederhauser G, Favre D, et al. Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta ceils [ J]. Diabetologia, 2007,50 ( 6 ) : 1304-1314. 被引量:1
  • 3Siebel AL, Natoli AK, Yap FY, et al. Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion[J]. Circ Res, 2013,113(2) :167-175. 被引量:1
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