摘要
目的:探讨辛伐他汀治疗高胆固醇血症的调脂作用。方法:2009年1月到2016年12月选择在我院诊治的高胆固醇血症患者204例,根据随机抽签原则分为观察组与对照组各102例,对照组给予单硝酸异山梨酯治疗,观察组在对照组治疗的基础上给予辛伐他汀治疗,两组都连续治疗3个月。结果:治疗后观察组与对照组的总有效率分别为98.0%和78.4%,观察组优于对照组(P<0.05)。治疗后观察组与对照组的TC含量为4.36±0.67mmol/L和5.33±0.71mmol/L,都低于治疗前的6.78±0.89mmol/L和6.81±0.91mmol/L(P<0.05),观察组治疗后TC含量也低于对照组(P<0.05)。结论:辛伐他汀治疗高胆固醇血症能发挥很好的调脂作用,促进胆固醇含量降低,提高治疗效果,值得临床上推广应用。
Objective： To investigate the lipid-lowering effect of simvastatin in the treatment of hypercholesterolemia. Methods： From January 2009 to December 2016,204 patients with hypercholesterolemia in our hospital were selected. They were divided into the observation group and the control group（ n = 102）,according to the random drawing principle. The control group was treated with isosorbide mononitrate,and the observation group was treated with simvastatin on the basis of the treatment of the control group. The two groups were treated continuously for 3 months. Results： After treatment,the total effective rate of the observation group and the control group was 98. 0% and 78. 4%,respectively,and the observation group was better than that of the control group（ P〈 0. 05）. After treatment,the TC content of the observation group and the control group was 4. 36 ± 0. 67 mmol/L and 5. 33 ± 0. 71 mmol/L,all lower than 6. 78 ± 0. 89 mmol/L and 6. 81± 0. 91 mmol/L before the treatment（ P〈 0. 05）. After treatment,the content of TC in the observation group was lower than that in the control group（ P〈 0. 05）. Conclusion： Simvastatin in the treatment of hypercholesterolemia can play a very good lipid-lowering effect,promote cholesterol content reduction,improve treatment effect. It is worthy of clinical application.
作者
牛俊娟
Niu Junjuan(Twelve worker＇s Hospital of Pingdingshan coal industry Medical Group of Henan Province 46700)
出处
《现代医用影像学》
2018年第4期1186-1187,1260,共3页
Modern Medical Imageology
关键词
辛伐他汀
高胆固醇血症
调脂作用
单硝酸异山梨酯
Simvastatin
Hypercholesterolemia
Lipid - lowering Effect
Isosorbide Mononitrate
