摘要
目的探讨血清核因子κB(NF-κB)、血管紧张素Ⅱ(AngⅡ)水平与原发性高血压(EH)早期肾损害之间的关系。方法入选96例原发性高血压患者,另选取同期50例健康体检者做为对照组。采用放射免疫分析法测定尿微量白蛋白(mALB)水平,根据mALB水平将入选高血压患者分为高血压伴肾损害组(A组)56例和高血压不伴肾损害组(B组)40例;同时采用酶联免疫吸附法(ELISA)测定血清NF-κB、AngⅡ水平。结果 A组和B组血清NF-κB、AngⅡ水平明显高于正常对照组,差异有统计学意义(P<0.05);与B组比较,A组血清NF-κB、AngⅡ水平明显更高,差异有统计学意义(P<0.05)。直线相关分析显示,血清NF-κB水平与收缩压、舒张压、mALB呈正相关(r=0.381、0.473、0.346,均P<0.05);血清AngⅡ水平与收缩压、舒张压、mALB呈正相关(r=0.507、0.431、0.375,均P<0.05)。结论 EH患者血清NF-κB、AngⅡ水平明显升高,EH伴早期肾损害患者更明显,提示NF-κB、AngⅡ可能参与了原发性高血压及其合并早期肾功能损害的发生发展。
Objective To investigate the relationships between serum nuclear factor-kappa B (NF-κB)and angiotensinⅡ(AngⅡ)levels and early renal damage in patients with essential hy-pertension (EH).Methods The levels of urinary microalbumin (mALB)were measured by ra-dioimmunoassay and levels of NF-κB and AngⅡ were determined by ELISA in 96 patients with EH and 50 healthy controls.According to the levels of mALB,these EH patients were divided in-to two groups:group A (56 patients with renal damage)and group B (40 patients without renal damage).Results Compared with healthy controls,serum NF-κB and AngⅡ levels significantly increased in patients with EH (P <0.05).Compared with group B,serum NF-κB and AngⅡ lev-els significantly increased in group A (P < 0.05).The systolic blood pressure,diastolic blood pressure and mALB levels were positively correlated with serum NF-κB levels (r=0.381,0.473 and 0.346,respectively;P <0.05),as well as with serum AngⅡ levels (r = 0.507,0.431 and 0.375,respectively;P <0.05).Conclusion Serum NF-κB and AngⅡ levels obviously increase in patients with EH,especially in patients with early renal damage,suggesting that NF-κB and AngⅡ may be involved in the occurrence and development of EH complicated by early renal damage.
出处
《实用临床医学(江西)》
CAS
2015年第7期21-23,共3页
Practical Clinical Medicine
关键词
原发性高血压
核因子ΚB
血管紧张素Ⅱ
早期肾损害
essential hypertension
nuclear factor-kappa B
angiotensinⅡ
early renal dysfunction