摘要
目的对胱抑素C和尿微量清蛋白2项含量进行检测,进而评价其在原发性高血压早期肾损害的临床应用。方法选取64例在高州市人民医院健康体检者和103例原发性高血压初诊患者,采用免疫透射比浊法检测尿微量清蛋白,采用乳胶增强散射免疫比浊法检测胱抑素C,分析比较健康体检者与原发性高血压组及不同原发性高血压水平亚组各参数指标的差别;并对各参数指标进行相关性分析。结果血清胱抑素C、尿微量清蛋白在高血压组均大于健康体检组,差异有统计学意义(P<0.05);原发性高血压亚组较健康对照组差异也有统计学意义(P<0.01)。结论血清胱抑素C和尿微量清蛋白含量随原发性高血压肾病的发生以及严重程度逐渐增高,可作为早期诊断原发性高血压肾病较敏感的指标,对于监测早期原发性高血压肾病的发生和病情发展程度有重要意义。
Objective To determination the content of cystatin C and urinary mAlb,and to evaluate the clinical application for early renal damage patients of essential hypertension.Methods 64 cases of healthy persons and 103 cases of essential hypertension patients were selected.Urinary mAlb was determined with immuneturbidimetric assay and cystatin C was determined with latex enhanced nephelometric immune assay.The difference of parameter among the healthy group,the essential hypertension group and the sub group was compared,and the correlation of various parameters was analyzed.Results Cystatin C and urinary mAlb in essential hypertension group were higher than that in the healthy group（P0.05）;The difference in the essential hypertension group,the sub group and the healthy group was statistically significant（P0.01）.Conclusion The level of serum cystatin C and urinary mAlb increase gradually as the essential hypertension nephropathy getting more severe.It could be used as a sensitive marker for early monitor the development and progress of essential hypertension nephropathy.
出处
《检验医学与临床》
CAS
2012年第9期1072-1073,共2页
Laboratory Medicine and Clinic
