摘要
【目的】探讨原发性高血压（EH）患者血清肿瘤坏死因子-a（TNF-α）、核转录因子-κB（NF-κB）水平变化及其临床意义。【方法】选择分级为Ⅰ、Ⅱ、Ⅲ级的E H患者各30例，并以30例健康者为对照，用酶联免疫吸附测定法（ELISA）检测血清中TNF-α、NF-κB水平。【结果】EH组血清 TNF-α、NF-κB水平明显高于正常组（ P ＜0．01）；EH不同级间患者血清TNF-α、NF-κB水平均有统计学差异（ P ＜0．05或 P ＜0．01），且随病情加重而升高。EH 组及 EH 不同级组 TNF-α水平与 NF-κB水平间均呈正相关（ P ＜0．05）。【结论】TNF-α、NF-κB可能参与EH的发生与进展，监测血清TNF-α、NF-κB水平可作为判断EH病情的指标。
[Objective]To explore the changes and clinical significance of serum tumor necrosis factor-α（TNF-α） and nuclear factor-κB（NF-κB） in patients with essential hypertension （EH） .[Methods] Patients with gradeⅠ（ n=30） ,Ⅱ（n=30） and Ⅲ（ n=30） EH were selected .Other 30 healthy patients were selected as the controls .Enzyme-linked immunosorbent assay （ELISA） was used to detect serum levels of TNF-αand NF-κB .[Results]Serum levels of TNF-αand NF-κB in EH group were obviously higher than those in normal group （ P〈0 .01） .There was significant difference in serum levels of TNF-αand NF-κB among patients with different grade of EH （ P〈0 .05 or P〈0 .01） . Serum levels of TNF-αand NF-κB increased with the exacerbation of EH .Serum levels of TNF-αin EH group and EH groups with different grade were positively correlated with NF-κB（ P〈0 .05） .[Conclusion] TNF-αand NF-κB may be involved in the incidence and progress of EH .The monitoring of serum TNF-αand NF-κB levels can be used as the indicators for assessing the condition of EH .
出处
《医学临床研究》
CAS
2014年第3期527-529,共3页
Journal of Clinical Research
