摘要
通过维尔斯迈尔-哈克反应、Michael加成、氢化还原和缩合等多步反应合成骨靶向抗肿瘤药物,目标药物总收率达24%,结构经1H-NMR、13C-NMR、IR和HR-ESI-MS表征。采用羟磷灰石晶体吸附实验考察目标物的骨靶向性,体外实验结果显示目标抗肿瘤药物有较好的骨靶向性。
The bone-targeted anticancer drugs were synthesized by multiple-step reactions including Vilsmeier-Haack reaction, Mi- chael addition reaction, hydrogenation reduction and condensation reaction, etc. The total yield of target drugs was 24%, and the structure of the target drugs were characterized and confirmed by ^1H-NMR, ^13C-NMR, IR and HR-ESI-MS. The object of bone targe-ting was studied by using hydroxyapatite crystals adsorption experiments. Experiments in vitro showed anti-tumor target drugs had good bone targeting.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2015年第7期1038-1041,共4页
Chemical Research and Application
基金
四川省教育厅项目(13ZB0222)资助
四川省大学生创新创业训练计划项目(201313705025)资助
关键词
骨靶向
骨肿瘤
药物合成
羟磷灰石
bone-targeted
bone tumors
drug synthesis
hydroxyapatite
