摘要
以5-取代吲哚为原料,经维尔斯迈尔-哈克反应制得5-取代吲哚-3-甲醛(2a^2e);2a^2e在DMF催化下,与盐酸羟胺反应制得5-取代吲哚-3-甲腈(3a^3e);3a^3e在H2O2和Na OH溶液中水解合成了5-取代吲哚-3-甲酰胺(4a^4e,4b^4e为新化合物),产率62.0%~75.0%,其结构经1H NMR,13C NMR和ESI-MS表征。
5-Substitued-indole-3-formaldehydes（2a^2e） were prepared by Vilsmeier-Haack reaction from 5-substituted indoles.5-Substituted indole-3-methyl cyanides（3a^3e） were obtained by the re-action of 2a^2e with hydroxylamine hydrochloride, using DMF as catalyst.5-Substituted indole-3-car-boxamides（4a^4e, 4b^4e were novel compounds） with yield of 62.0%~75.0% were synthesized by hydrolyzation of 3a^3e in H2 O2-NaOH solution.The structures were characterized by 1 H NMR, 13 C NMR and ESI-MS.
出处
《合成化学》
CAS
CSCD
2016年第8期697-700,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21072111
21272131)
