摘要
以取代吲哚为原料,经维尔斯迈尔-哈克反应制得取代吲哚-3-甲醛,再通过DMSO/NaOH体系制得N-取代吲哚-3-甲醛(3a^3g);3a^3g经Na BH4还原合成了7个未见文献报道的取代吲哚-3-甲醇类衍生物(4a^4g),其结构经~1H NMR,^(13)C NMR和MS表征。
N-substituted indole-3-formaldehydes（3a-3g） were synthesized in the system of dimethyl sulfoxide and sodium hydroxide by reation of substituted indole-3-formaldehydes,which were obtained by Vilsmeier-Haack reaction of substituted indoles.Seven novel substituted indole-3-methanols were synthesized by reduction of 3a-3g with sodium borohydride as the reagent.The structures were characterizd by ^1H NMR,^13C NMR and MS.
作者
刘益州
王新颖
徐栋栋
郑程隆
康从民
LIU Yi-zhou WANG Xin-ying XU Dong-dong ZHENG Cheng-long KANG Cong-min(College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, Chin)
出处
《合成化学》
CAS
CSCD
2017年第1期56-59,63,共5页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21272131)
