摘要
目的:总结乳腺癌骨转移病变治疗的新进展。方法:应用Medline及CNKI期刊全文数据库检索系统,以"乳腺癌、骨转移瘤和治疗"等为关键词,检索2004-2009年的相关文献,共检索到731条,纳入标准:1)骨转移瘤的特点和表现;2)骨转移肿瘤的核素治疗、放疗、手术治疗和化疗治疗;根据纳入标准,精选分析25篇文献。结果:乳腺癌患者病程中常见骨转移,治疗有双磷酸盐药物,化疗、放疗、放射性核素治疗和手术等,CT引导下的射频治疗是相对新的治疗方法,也有联合放疗和靶向药物治疗的实验研究在开展中。结论:针对乳腺癌骨转移瘤患者,长期、持续、有效的治疗方法是根据患者情况,选择性采用不同治疗措施的综合治疗。
OBJECTIVE：The data on the pathophysiology,mechanisms and treatment of bone pain of Osseous Metastases from breast cancer was investigated. METHODS： A total of 731 papers were searched with osseous metastases,breast cancer,treatment as key words in medline and CNKI database from 2004 to 2009,and 25 papers were selected according to the standards： 1）charactors and expression of osseous metastases;2）treatment methods of osseous matasteas. RESULTS： 1） Breast cancer has a predilection for dissemination to bone. 2） A number of different methods have been proposed for pain relief in cancer patients with bone metastases,each with different indications,contraindications and complications （systemic analgesics,bisphosphonates,antitumor chemotherapy,radiotherapy,systemic radio-isotopes. CT-guided radiofrequency （RF） ablation is a relatively new method. CONCLUSIONS： In order to prevent pathological fractures and to give the breast cancer patient a definitive treatment,as the advances in the management of cancer prolong the survival of these patients,the strategy of systemic treatment（combining radiation,bisphosphonates and orthopedic vertebroplasty appears to be effective option.
出处
《中华肿瘤防治杂志》
CAS
2009年第18期1435-1438,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
乳腺肿瘤
骨转移瘤
治疗
综述文献
breast neoplasms
osseous metastases
therapy
review literature
