摘要
目的 :探讨伊班膦酸和唑来膦酸对脊柱骨巨细胞瘤的作用及安全性。方法 :将60例进行脊柱骨巨细胞瘤病灶切刮植骨术的患者随机分为A组和B组,A组30例患者手术后静脉滴注伊班膦酸(4 mg/月,1次/月),共1年。B组30例患者手术后静脉滴注唑来膦酸(4 mg/月,1次/月),共1年。比较2组患者手术时间、手术出血量和伤口愈合情况,应用视觉模拟评分法(visual analogue scale,VAS)和Oswestry功能障碍指数(Oswestry disability index,ODI)评估2组患者手术前及手术后的疼痛症状,并进行复发率、病灶骨化率和不良反应发生率比较。结果 :2组患者的手术时间、手术时出血量和伤口愈合情况之间的差异无统计学意义(P值均>0.05)。2组患者经手术及伊班膦酸或唑来磷酸治疗后,VAS和ODI均有改善(P值均<0.05)。A组患者的复发率高于B组(10.0%vs3.3%,P=0.01),A组患者病灶骨化率低于B组(78.6%vs 91.5%,P=0.04),A组患者的不良反应发生率低于B组(40.0%vs 70.0%,P<0.01)。结论 :脊柱骨巨细胞瘤切刮植骨术后应用伊班膦酸和唑来膦酸进行辅助治疗均取得良好效果,治疗过程中需注意药物不良反应。
Objective：To investigate the efficacy and safety of ibandronate and zoledronic acid in treatment of giant cell tumor of spine.Methods：Sixty patients who had undergone surgical resection and bone grafting for giant cell tumor of spine were randomly divided into group A（n = 30,postoperative intravenous drip infusion of 4 mg ibandronate monthly for one year） and group B（n = 30,postoperative intravenous drip infusion of 4 mg zoledronic acid monthly for one year）.The operation time,intraoperative blood loss and wound healing between two groups were compared.Preoperative and postoperative visual analogue scale（VAS） and Oswestry disability index（ODI） were evaluated and compared.The recurrence rate,ossification rate and incidence rate of adverse reactions were analyzed.Results：There were no statistically significant differences in operation time,intraoperative blood loss and wound healing between two groups（all P 〉 0.05）.The improvement of VAS and ODI scores of two groups after operation and treatment with ibandronate or zoledronic acid were significantly improved（both P 〈 0.05）.The recurrence rate of group A was higher than that of group B（10.0%vs 3.3%,P = 0.01）.The ossification rate of the lesions of group A was lower than that of group B（78.6%vs 91.5%,P = 0.04）.The incidence rate of adverse reactions of group A was lower than that of group B（40.0%vs 70.0%,P 〈 0.01）.Conclusion：Administration of ibandronate and zoledronic acid after surgical resection and bone grafting for giant cell tumor of spine can achieve good efficacy,while the adverse reactions of the treatment should be noted.
出处
《肿瘤》
CAS
CSCD
北大核心
2016年第3期334-339,357,共7页
Tumor
关键词
骨肿瘤
脊柱
复发
二膦酸盐类
有效性研究
Bone neoplasms
Spine
Recurrence
Diphosphonates
Validation studies
