摘要
目的:探讨17β-雌二醇片阴道给药在激素补充疗法(HST)冻融胚胎移植(FET)子宫内膜准备中应用时血清雌二醇(E2)水平、内膜厚度、内膜形态与妊娠的关系,并分析不同剂量17β-雌二醇片对血清E2水平、内膜厚度、内膜形态及妊娠率的影响。方法:就诊于我院生殖中心行冻融胚胎移植的无排卵型不孕妇女90例,根据临床结局分为妊娠组(49例)和未妊娠组(41例),分析胚胎种植结局与血清E2和孕酮(P)水平、内膜厚度及内膜形态的关系;根据17β-雌二醇片给药剂量不同分为2组:A组(1 mg)和B组(2 mg),比较2组患者内膜厚度、内膜形态、内膜转换日E2水平、移植日E2水平、胚胎种植率和妊娠率是否有差别。结果:临床妊娠率为54.44%(49/90),胚胎种植率为34.71%(59/170)。妊娠组与未妊娠组比较:2组患者的年龄、不孕年限、内膜厚度、内膜转换日E2、移植日E2和移植胚胎数比较,差异均无统计学意义(P>0.05);2组患者的内膜形态比较,妊娠组A型内膜比例明显高于未妊娠组,差异有统计学意义(P<0.05)。A组与B组比较:A组患者内膜转换日E2和移植日E2明显低于B组,差异有统计学意义(P<0.05);但2组患者药物治疗天数、内膜厚度、内膜形态、胚胎种植率和妊娠率比较,差异均无统计学意义(P>0.05)。结论:17β-雌二醇片阴道给药适合用于无排卵型不孕妇女冻融胚胎移植周期的子宫内膜准备,血清激素水平、子宫内膜厚度和临床妊娠率均可达到满意的效果;17β-雌二醇片1 mg可达到与2 mg相当的内膜厚度和妊娠率;内膜形态是影响胚胎种植结局的重要因素。
Objective： To investigate the relationship between pregnancy and serum estradiol（E2） levels, endometrial thickness, endometrial pattern in patients using vaginal administration of 17β-estradiol in frozenthawed embryo transfer（FET）. And to analyze the effect of using the different dose of 17β-estradiol on serum（E2） levels, endometrial thickness, endometrial pattern and pregnancy rate. Methods： A total of 90 patients of anovulia induced barrenness were undergone frozen embryo transfer in the Reproduction Medical Center of the Second Affiliated Hospital of Wenzhou Medical University from June 2013 to May 2014. The relationship between serum estradiol（E2） levels, endometrial thickness and endometrial pattern was investigated in two groups including pregnant group（n=49） and non-pregnant group（n=41） according to clinical outcome. All the patients were divided into two groups： group A（vaginal estrogen 1 mg） and group B（vaginal estrogen 2 mg）. The difenrences of their sesum E2 levels, endometrial thickness, endometrial pattern and pregnancy rate were compared between the two groups. Results： The clinical pregnancy rate was 54.00%（49/90）, the implantation rate was 34.71%（59/170）. There were no satistical diffefence in patients＇ age, infertile years, endometrial thickness of uterus, number of embryos transferred, E2 and P levels on the day injection of progesterone and on transplant day between pregnant group and non-pregnant group. The proportion of type A endometrium in pregnant group were significantly higher than that in non-pregnant group（P〈0.05）. E2 levels on injection of progesterone, E2 levels on transplant day were significantly lower in group A compared with group B（P〈0.05）. No significant difference were shown in the mean of endometrial thickness of uterus, endometrium patterns, P levels ontransplant day, the clinical pregnancy rate and the implantation rate. Conclusion： Our study shows that it is suitable for patients with anovuliain frozen embry
出处
《温州医学院学报》
CAS
2015年第6期413-416,共4页
Journal of Wenzhou Medical College
基金
浙江省人口和计划生育科技计划项目(JSW2013-B023)
关键词
17Β-雌二醇
阴道给药
冻融胚胎移植
内膜准备
妊娠率
17β-estradiol
vaginal administration
frozen-thawed embryo transfer
endometrial preparation
pregnancy rate
