摘要
目的通过探讨芬吗通对卵巢储备功能下降(DOR)及卵巢早衰(POF)患者的临床改善情况,及其对患者血清中性激素及血脂的影响。方法筛选本院生殖医学科门诊和住院部2009年3月至2013年12月确诊的120例DOR和POF的患者纳入研究,将病人随机分为芬吗通治疗组和人工周期治疗组,各60人。随后按照FSH水平,将患者分为DOR(10U/L<FSH<40U/L)和POF(FSH>40U/L)组。比较两组患者经1个疗程的治疗后的临床治疗效果(症状改善情况)、血清性激素和血脂的变化。结果 (1)芬吗通治疗后,DOR和POF组患者血清FSH、LH水平较治疗前均出现下降,但差异无统计学意义(P>0.05);DOR患者治疗后E2值水平比治疗前略有下降,但差异无统计学意义(P>0.05),而POF患者治疗后E2值水平比治疗前显著上升(P<0.05)。人工周期治疗组中,DOR和POF患者治疗后血清FSH和LH水平较治疗前均下降,但差异均无统计学意义(P>0.05);DOR患者治疗后E2值水平比治疗前略有下降,而POF患者治疗后E2值水平比治疗前上升,但差异均无统计学意义(P>0.05)。(2)两组患者治疗后与治疗前相比较,HDL-C值显著上升,TC、TG及LDL-C值均下降,差异有统计学意义(P<0.05)。芬吗通治疗组与人工周期治疗组比较,治疗后TC、TG、HDL-C及LDL-C值差异有统计学意义(P<0.05)。(3)芬吗通治疗组的有效率优于人工周期治疗组;芬吗通治疗组中DOR和POF患者的治疗效果显著高于人工周期治疗组同类患者(P<0.05)。结论 DOR及POF患者通过芬吗通的治疗,能够有效降低患者的血脂水平,改善血清性激素水平,有效缓解患者的临床症状,其疗效与传统人工周期性激素替代疗法有等效性。
Objective：To evaluate the therapeutic effect of Femoston in treatment of patients with decline of ovarian reserve（DOR）or premature ovarian failure（POF）.Methods：A total of 120 patients with DOR or POF from the Reproductive Department of Affiliated Hospital of Hebei University from March 2009 to December 2013 were randomly divided into two groups：Femoston treatment group and artificial cycle treatment group.According to FSH levels,the patients were subdivided to DOR（10 U/LFSH 40 U/L）and POF patients（FSH 40 U/L）.The condition of symptomatic improvement,variations of sex hormones and blood lipids levels were evaluated after one course of treatment.Results：After Femoston treatment,FSH and LH levels were declined,but there were no significant difference compared with those of before treatment in DOR and POF patients（P0.05）.E2 levels were declined in DOR patients but no significant difference（P 0.05）,while E2 levels were significantly increased in POF patients（P0.05）.After artificial cycle treatment,FSH and LH levels were declined but not significantly different compared with those of before treatment in DOR and POF patients（P0.05）.E2levels were declined in DOR patients and increased in POF patients,but there were no significant differences（P0.05）.The HDL-C levels were significantly increased and TC,TG LDL-C levels were significantly decreased after either treatment（P0.05）.There were significant differences in HDL-C,TC,TG LDL-C levels between Femoston treatment group and artificial cycle treatment group（P0.05）.The therapeutic effect of Femoston was significantly better than that of artificial cycle treatment either in DOR or POF patients（P0.05）.Conclusions：Femoston treatment in DOR and POF patients can effectively decrease lipids levels,improve reproductive hormone levels in serum and relieve clinical symptoms.The effect of Femoston treatment was comparable with artificial cycle treatment.
出处
《生殖医学杂志》
CAS
2015年第3期225-229,共5页
Journal of Reproductive Medicine
关键词
芬吗通
卵巢储备功能下降
卵巢早衰
Femoston
Decline in ovarian reserve
Premature ovarian failure
