摘要
选用４月龄ＳＤ雌性大鼠随机分为切除卵巢去势组、假手术组、切除卵巢＋尼尔雌醇组（０．１５ｍｇ／１００ｇ体重，每周１次）及切除卵巢＋炔雌醇（０．２μｇ／１００ｇ体重，ｑｄ×５）组。用计算机图象分析技术，对各组大鼠宫内膜进行形态计量测定，以探讨雌激素预防去势大鼠骨质疏松时对宫内膜的影响。结果显示：用药１０周，尼尔雌醇及炔雌醇能有效预防去势大鼠的失骨，尼尔雌醇组宫内膜增生不明显，为增生早期的改变；炔雌醇组宫内膜明显增生，以腺体为主，并可见灶性非典型增生。４组宫内膜形态计量结果有明显差别。由此提示用雌激素预防绝经后骨质疏松，尼尔雌醇较安全。
This study was designed to evaluate the effect of estrogen on rat endometrium and compare the results of Nilestriol and Estradiol replacement therapies for preventing osteoporosis in ovariectomized rats. Forty 4month old SD female rats were randomly divided into four groups, namely sham operation, bilateral ovariectomy, ovariectomy plus supplementary ethinyl estradiol (0.2μg/100g B.W. qd×5), and ovariectomy plus supplementary Nilestriol (0.15mg/100g B.W.once a week). Computerized image analyzer was used to evaluate the endomitrial pathological changes 10 weeks later. The results showed an atrophied endometrium in ovariectomized group, a slightly proliferative endometrium in Nilestriol treated group, and a markedly proliferative endometrium with local atypical hyperplasia in estradiol treated group. The difference between group 3 and group 4 in morphometry was significant (P<0.5). These suggest the relative safety of Nilestriol replacement therapy for preventing menopausal osteoporosis.
出处
《华西医科大学学报》
CSCD
1998年第3期295-297,共3页
Journal of West China University of Medical Sciences
