摘要
目的比较双相Ⅰ型障碍缓解期患者与抑郁发作期患者的神经认知功能。方法回顾性分析我院收治的65例双相Ⅰ型障碍患者的临床资料,其中缓解期患者31例(缓解期组),抑郁发作期患者34例(发作期组),并选取同期健康体检者30例为对照组。对三组受试者的汉密顿量表(HAMD)、大体功能评定量表(GAF)、总体认知功能评分进行评价和比较。结果发作期组患者的HAMD评分为(16.53±4.48)分,明显高于缓解期组患者的(4.21±1.92)分和对照组的(1.75±0.33)分,而缓解期组的HAMD评分明显高于对照组,差异均有统计学意义(P<0.05);发作期组的GAF评分为(58.41±15.73)分,明显低于缓解期组的(74.27±14.62)分和对照组的(91.54±4.64)分,缓解期组的GAF评分明显低于对照组,差异均有统计学意义(P<0.05);发作期组的总体认知功能评分明显低于缓解期组和对照组,缓解期组总体认知功能评分明显低于对照组,差异均有统计学意义(P<0.05)。结论双相Ⅰ型障碍患者神经认知功能显著降低,其中抑郁发作期神经认知功能低于缓解期。
Objective To compare the neurocognitive function of bipolar I disorder patients ofeuthymia or depression stage. Methods Sixty-five patients with bipolar I disorder in our hospital were retrospectively analyzed, including 31 patients of euthymia stage （euthymia group） and 34 patients of depression stage （depression group）. And 30 healthy people were selected as the control group. The Hamilton Depression Scale （HAMD）, Global Assessment of Functioning （GAF） Scale, and general cognitive function level of three groups were tested and compared. Results The HAMD score of depression group was （16.5±4.48）, which was significantly higher than euthymia group （4.21±1.92） and control group （1.75±0.33）, P〈0.05. The HAMD score of euthymia group was significantly higher than control group （P〈0.05）. The GAF score of depression group was （58.41±15.73）, which was significantly lower than euthymia group （74.27±14.62） and control group （91.54±4.64）, P〈0.05. The GAF score of euthymia group was significantly lower than control group （P〈0.05）. The general cognitive function level of depression group was significantly lower than euthymia group and control group （P〈0.05）, and the level of euthymia group was significantly lower than control group （P〈0.05）. Condusion Neurocognitive function of bipolar I disorder patients is lower than that of healthy people, and the function of patients of depression stage is lower than those of euthymia stage.
出处
《海南医学》
CAS
2015年第12期1751-1753,共3页
Hainan Medical Journal
基金
广州市医药卫生科技项目(编号:20121A011097)
关键词
双相Ⅰ型障碍
缓解期
抑郁
神经认知功能
Bipolar I disorder
Euthymia
Depression
Neurocognitive function
