摘要
目的 分析经纤维支气管镜肺灌洗最大灌洗量影响因素，为筛选尘肺肺灌洗对象及初步预测灌洗疗效提供科学依据。方法收集238例尘肺患者经纤维支气管镜肺灌洗术中最大灌洗量影响因素，分析灌洗量与患者病情分期、肺功能、体质量指数的关系，建立多元线性回归模型，筛选出对影响肺灌洗量有重要意义的因素。结果经纤维支气管镜大容量肺灌洗术中灌洗量与病情分期无关，不同期别尘肺灌洗量比较，差异无统计学意义（P〉0．05），多元线性回归分析显示RV及RV／TLC与肺灌洗量关系密切，由标准回归系数可以看出，RV（-0．234）对灌洗量有显著性影响。结论尘肺期别不是影响肺灌洗量的主要因素，RV及RV／TLC是影响肺灌洗量的主要因素，RV是预测肺灌洗量的强有力的因子。本研究建立的优化方程可初步筛选肺灌洗患者并预测肺灌洗疗效，值得临床参考。
Objective To analysis the influential factors of lavage volume of pneumoconiosis bylung lavage,provide a scientific basis for screening lung lavage object of pneumoconiosis and preliminary forecast lavage efficacy. Methods Collect the 238 cases of pneumoconiosis influence factors of lavage volume and analysis the relationship between lavage volume in patients with staging,lung function, body index,establish a model of multiple linear regression analysis and screen out the factors are of great significance to the effect of lavage volume. Results The lavage volume has no necessary relationship with pneumoconiosis stages and there was no statistically significant between different pneumoconiosis stages （P 〉0.05）, multiple linear regression analysis showed a close relationship between RV and RV/TLC and lung lavage volume,by the regression coefficient can be seen that the RV （-0. 234） has a significant effect on lavage volume. Conclusions Pneumoconiosis stages is not the main reference index of lung lavage volume,RV and RV/TLC are the main factors affect the lung lavage,RV is a powerful predictor of the lung lavage. This research established the optimization equation can be a preliminary screening of patients with lung lavage and preliminary predict lung lavage curative effect, it is worhy of clinical promotion.
出处
《国际呼吸杂志》
2015年第11期850-852,共3页
International Journal of Respiration
基金
湖南省科技厅重点科研项目（2011SK2020）
