摘要
目的:研究双肺大容量灌洗治疗对煤工尘肺患者肺功能及6分钟步行试验的影响。方法:入选29例已明确诊断为煤工尘肺的患者,行双肺大容量灌洗,并于灌洗前、灌洗后2周分别询问其症状,行6分钟步行试验及肺功能检查。结果:29例煤工尘肺患者在行双肺大容量灌洗后,与灌洗前相比胸闷、呼吸困难明显改善(P<0.05),但是咳嗽、咳痰等症状的改善无统计学意义(P>0.05)。患者在行双肺大容量灌洗前肺功能表现为小气道功能受损或阻塞性通气功能障碍者有17人。和灌洗前相比,这组患者最大通气量(MVV)和6分钟步行试验明显改善,分别为(96.8±14.1)%vs(91.2±15.2)%,(448.8±60.7)mvs(422.6±46.2)m,而肺总量(TLC)较灌洗前降低(119.4±15.0%vs115.8±14.7%,P<0.05)。结论:双肺大容量灌洗治疗在短时间内可以改善症状,提高患者的肺功能及运动耐量,提高患者的生活质量。
Objective：To evaluate the effects of massive whole-lung lavage on pulmonary function and six-minute walk distance in patients with coal workers’ pneumoconiosis. Methods：Twenty-nine patients with coal workers’ pneumoconiosis were recruited. Pulmonary function tests and six-minute walk test were completed before and 2 weeks after massive whole-lung lavage respectively,and the symptoms were recorded. Results：Following massive whole-lung lavage,dyspnea and chest tightness were alleviated significantly, but no remarkable change was found in cough and sputum. Baseline pulmonary function testing identified 17 patients with damage of small airway or obstructive ventilation dysfunction. Compared with parameters before massive whole-lung lavage,maximal ventilatory volume （MVV） and six-minute walk distance were significantly improved [（96.8±14.1）% vs （91.2±15.2）%;（448.8±60.7）m vs （422.6±46.2）m],and total lung capacity （TLC） was significantly reduced [（119.4%±15.0）% vs （115.8±14.7）%,P〈0.05]. Conclusion： This study indicated that massive whole-lung lavage can improve symptoms,pulmonary function,exercise tolerance and life quality in patients with coal workers’ pneumoconiosis.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2010年第3期412-415,共4页
Journal of Nanjing Medical University(Natural Sciences)
关键词
煤工尘肺
双肺大容量灌洗
肺功能
6分钟步行试验
coal workers＇ pneumoconiosis
massive whole-lung lavage
pulmonary function
six-minute walk test
