摘要
目的综合评价血管紧张素转化酶（angiotensin converting enzyme，ACE）I／D基因多态性与中国汉族人群特发性肺间质纤维化（idiopathic pulmonary fibrosis，IPF）关系。方法应用计算机检索PubMed、Cochrane Library、中国学术期刊全文数据库、维普数据库和万方数据库，按纳入、排除标准选择纳入ACE基因I／D多态性与IPF关系的病例对照研究，评价纳入研究质量，并采用Stata 12．O进行定量分析。结果共纳入4个符合条件的病例对照研究，其中IPF组310例，对照组364例。Meta分析结果显示，所有模型中未见统计异质性，故均采用固定效应模型。等位基因（D VS I）、共显性模型（DDVSⅡ）及隐性模型（DD VS DI＋Ⅱ）合并OR分别为[OR=1．701，95％CI（1．365，2．121）]、[OR=2．086，95％CI（1．403，3．102）]及[OR-2．544，95％CI（1．826～3．544）]（P值均〈O．05）。结论ACE基因I／D多态性与中国汉族人群IPF的发病有密切关系，D等位基因和DD基因型是IPF的危险因素。但由于纳入文献数量较少，还需大样本、多中心研究进一步验证。
Objective To evaluate the relationship of angiotensin-converting enzyme （ACE）I/Dgene polymorphism with idiopathic pulmonary fibrosis （IPF）. Methods We electronically searched PubMed, Cochrane Library, China Academic Journals Full-text database, VIP Database, Wanfang database,and collected the ACE I/D gene polymorphism and IPF relationship between case-control study among the Han Chinese population, and assessed the quality of the included studies. The data were analyzed by Stata 12.0 software. Results We included 4 articles,including 310 cases in IPF group and 364 cases in the control group. Meta-analysis results showed that there was no statistical heterogeneity in all models,therefore the fixed effects model were adopted. The combined OR in allele （D vs I）, co-dominant model （DD vs II） and recessive model （DD vs DI ＋ Ⅱ） were [ OR =1. 701,95%CI （1. 365,2. 121）], [OR =2.086,95% CI （1.403,3.102）],[OR =2.544,95% CI （1. 826～3. 544）] （all P 〈0.05） respectively. Conclusions The ACE gene I/D polymorphism is closely related to the pathogenesis of IPF in Chinese Han population,D allele and DD genotype is a risk factor for IPF. However,due to the small number of the researches included,it is also need a large sample, multi-center study to further verify.
出处
《国际呼吸杂志》
2015年第11期844-849,共6页
International Journal of Respiration
