摘要
目的:探讨脑出血(ICH)患者血管紧张素转换酶(ACE)I/D基因多态性,并分析其是否有致脑出血效应。方法:应用聚合酶链式反应-限制性片断长度多态性(PCR-RFLP)技术检测80名ICH患者和90名健康对照者的ACE基因型和等位基因,并用Logistic回归分析其致脑出血的效应。结果:170例样本中ICH组ACE DD基因型频率为35.0%,D等位基因频率51.9%,明显高于正常对照组(P<0.05);经Logistic回归分析,ACE DD基因型发病的相对危险度(OR)为2.923,与ACE非DD基因型OR值0.582相比差异有统计学意义(P<0.05),ACE DD基因型增加脑出血发生的概率。结论:ACE I/D基因多态性可能是ICH发病的独立遗传因素。
Objective： To identify an angiotensin I - converting enzyme （ACE） gene polymorphisms of the patients with intracerebral hemorrhage and analyze its causative effect on intraacerebral hemorrhage. Methods： ACE genotypes were examined with the method of PCR - RLFP in 80 patients with intracerebral hemorrhage （ICH） and 90 age - matched controls. Independent fatalness of ACE genotypes and alleles towards intracerebral hemorrhage were analyzed by Logistic regression. Results ： ACEI/D genotype frequency（35.0% ） and D alleles frequency（51.9% ） in ICH group were remarkably higher than that in the control group （P 〈 0.05 ）. Logistic regression analysis showed that there was significant difference in the incidence risk between ACE I/D genotype （OR = 2. 923 ） and ACE non -I/D genotype （OR = 0. 582 ）, and that ACEI/D genotype can increase the incidence risk of ICH. Conclusion ： The gene polymorphism of ACE I/D is related to the incidence of ICH and may be the independent risk factor for intracerebral hemorrhage.
出处
《包头医学院学报》
CAS
2008年第2期117-118,共2页
Journal of Baotou Medical College
基金
包头市医药卫生基金项目(BK2003121)
