摘要
目的 对中国汉族人血管紧张素I转换酶(ACE)基因内含子16插入(I)/缺失(D)多态性与糖尿病肾病(DN)的关联性进行Meta-分析。方法 以DN组和糖尿病非DN对照组基因型分布的OR值为统计量。全面检索到相关文献,剔除不符合要求的文献,应用REVMAN3.1软件对各研究结果进行一致性检验和采用相应的数学模型进行数据合井。结果 病例组比对照组的合并OR值及其95％可信区间为:NIDDM组12篇文献DD/ID+II和II/ID+DD合并OR值分别为2.17(1.74-2.70)和0.49(0.36-0.66);IDDM组3篇文献DD/ID+II和II/ID+DD合并OR值分别为3.92(2.05-7.47)和0.19(0.09-0.43)。P值均小于0.01。结论 中国汉族人ACE/ID多态性与DN有关联,DN患者DD基因型多,II基因型少。
Objective To study the association between the insertion(I)/deletion(D) polymorphism of the angiotensin-converting enzyme gene intron 16 (ACE/ID) and diabetic nephropathy(DN) among Chinese population by Meta-analysis. Methods Odds ratios of ACE/ID genotype distributions were analyzed in NIDDM or IDDM patients with and without DN. All the related studies on ACE/ID polymorphism and DN were identified while poor-qualified studies were excluded, and the risk of publication bias was estiMetad. The Meta-analysis software, REVMAN3.1, was applied for investigating heterogeneity among individual studies and summarizing effects across studies by proper statistical methods. Results The pooled odds ratios (with 95% CI) of DD vs ⅠD+ Ⅱ and Ⅱ vs ⅠD + DD were 2.17(1.74 - 2.70) and 0.49(0.36 - 0.66) in NIDDM(12 studies), 3.92(2.05 - 7.47) and 0.19(0.09 - 0.43) in IDDM (3 studies) respectively (P<0.01) . Conclusion In both NIDDM and IDDM, ACE/ID polymorphism is believed to be associated with diabetic nephropathy. The number of DN patients with DD genotype has been increased while that with Ⅱ genotype decreased.
基金
天津市教委2001年科研基金资助。
