摘要
目的探讨血管紧张素I转换酶（ACE）基因I／D多态性在特发性肺纤维化（IPF）发病中的作用。方法应用PCR技术检测42例IPF患者（IFP组）和90例健康查体者（对照组）ACE基因I／D多态性，并分析不同基因型和等位基因者IPF发病危险性。结果IPF组DD基因型和D等位基因频率均显著高于对照组（P〈0．05）；与Ⅱ基因型比较，携带DD型和D等位基因个体发生IPF的风险分别增加2．97倍（95％CI为1．13—7．73）和1．96倍（95％CI为1．16—3．32），P均〈0．05。结论ACE基因I／D多态性与IPF发病有关，DD基因型和D等位基因可能增加IPF的患病风险。
Objective To investigate the effect of angiotensin converting enzyme（ACE） gene insertion/deletion（I/D） polymorphism in the pathogenesis of the idiopathic pulmonary fibrosis（IPF）. Methods The ACE gene I/D polymorphism was determined by PCR in 42 IPF patients （ IPF group） and 90 normal controls（ control group）. Occurrence risk of the individuals with different genetype and allele were analyzed. Results The frequencies of DD genetype and D allele in the IPF group were both higher than those in the control group （P 〈0.05）. As compared with II genotype,the individuals with DD genotype and D allele were 2.97 （95 % CI： 1.13 -7.83 ） and 1.96 （95 % CI： 1.16 -3.32 ） times susceptible to IPF, both P 〈 0.05. Conclusions ACE gene I/D polymorphism is associated with the pathogenasis of IPF. The DD genotype and D allele may increase the risk of IPF.
出处
《山东医药》
CAS
北大核心
2010年第3期13-15,共3页
Shandong Medical Journal
基金
潍坊市科学技术发展计划项目(200702061)
关键词
肺纤维化
特发性
血管紧张素转换酶
多态性
pulmonary fibrosis
idiopathic
angiotensin converting enzyme
polymorphism
