摘要
目的:研究区域动脉灌注(LA I)治疗对重症急性胰腺炎(SA P)患者炎性因子的影响。方法:46例SA P患者随机分为两组,对照组26例常规静脉给药,治疗组20例采用持续性LA I治疗。比较两组患者血炎性因子IL-1、IL-6和TN F-α及血淀粉酶的含量,分析临床治疗效果。结果:经治疗后两组患者的炎性因子水平及血淀粉酶的含量均下降,与对照组比较,治疗组下降较迅速(P<0.05)。治疗组并发症发生率25.0%,病死率10.0%,对照组分别为34.6%、15.4%,治疗组低于对照组,差异有统计学意义(P<0.05)。结论:LA I对SA P是安全有效的治疗手段,优于经静脉途径治疗。
Objective：To study the effect of local arterial infusion（LAI） on cytokines of medicine with severe acute pancreatitis（SAP）.Methods：The clinical data of 46 case of SAP were randomly and divided into two groups：Group A（control group,n=26） admitted received only the routine therapy and Group B（treatment group,n=20） admitted received LAI therapy.The changes of interleukin-1 （IL-1）,interleukin-6（IL-6） and tumor necrosis factor-α （TNF-α） in blood were measured,and the curative effects of the two groups were compared.Results：The treatment decreased significantly the levels of IL-1,IL-6 and TNF-α in blood（P＜0.05）,especially in group B（P＜0.05）.Compared to group A,the mortality and morbidity in group B were statistically reduced.Conclusion：Regional arterial infusion is an effective and safe treatment of SAP,and LAI is more effective than intravenous injection.
出处
《中国现代普通外科进展》
CAS
2015年第4期285-287,共3页
Chinese Journal of Current Advances in General Surgery
关键词
重症急性胰腺炎
区域动脉灌注
静脉给药
Severe acute pancreatitis
Local arterial infusion
Intravenous injection
