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尿激酶区域动脉灌注治疗大鼠重症急性胰腺炎的实验研究 被引量:5

Effects of urokinase by local aterial infusion on rats with severe acute pancreatitis
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摘要 目的 探讨尿激酶区域动脉灌注 (LAI)对重症急性胰腺炎 (SAP)大鼠微循环的影响。方法 以 5 %牛磺胆酸钠胰胆管注射 (1ml/kg )制成大鼠急性胰腺炎模型 ,以生理盐水LAI为对照 ,检测血浆和全血粘度 ,观察胰腺病理变化 ,并以激光多普勒检测大鼠胰腺血流量。结果 SAP血浆和全血粘度明显升高 ,血流量下降 ,与正常组对比有显著差异 (P <0 0 5 ) ;尿激酶LAI则使SAP大鼠血浆和全血粘度降低 ,血流量上升 ,但与对照组及正常组对比均有显著差异 (P <0 0 5 )。结论 尿激酶LAI能改善SAP大鼠胰腺微循环 ,但不能完全阻止SAP的病理演变。 Objective To investigate the effects of urokinase by local aterial infusion on (LAI) rats with severe acute pancreatitis(SAP). Methods SAP was induced in rats with retrograde infusion of 5% sodium taurocholate into the pancteatobiliary duct(1ml/kg), and normal saline LAI was used as control. Viscosity of whole blood and plasma were measured, and pathological study of pancreas was performed. Pancreatic blood flow was measured by laser Doppler instrument. Results Viscosity of whole blood and plasma of rats with SAP increased significantly, and pancreatic blood flow decreased. There were significantly difference between normal and SAP( P <0.05). Viscosity of whole blood and plasma of rats with SAP treated with urokinase LAI decreased significantly, and pancreatic blood flow increased compared with group SAP, normal and contol. Conclusions Urokinase LAI can ameliorate the microcirculation of rats with SAP, and it can't completely prevent the pathological course of SAP.
出处 《中华肝胆外科杂志》 CAS CSCD 2003年第10期616-618,共3页 Chinese Journal of Hepatobiliary Surgery
基金 深圳市科学技术研究基金项目 (2 0 0 0 0 40 3 3 )
关键词 尿激酶 动脉灌注 治疗 大鼠 重症急性胰腺炎 SAP 急腹症 血液流变学 Pancreatitis Urokinase Local aterial infusion Microcirculation
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