摘要
目的探讨慢性阻塞性肺疾病（COPD）与幽门螺杆菌（HP）感染的关系。方法选择2010年1月~2014年1月魏县第二人民医院收治的COPD患者110例作为COPD组,60例健康体检者作为对照组,采用酶联免疫法检测两组患者IL-6、IL-17及HP-Ig G抗体水平,对COPD患者进行第1秒最大呼气量（FEV1）、用力肺活量（FVC）、FEVl/FVC值、氧分压（PO2）、二氧化碳分压（PCO2）和血氧饱和度（Sa O2）检测。结果 COPD组HP-Ig G检测阳性率高于对照组（70.9%vs46.7%,χ2=9.720,P=0.002）;COPD组血清IL-6、IL-17水平及HP-Ig G滴度均高于对照组[（11.75±4.16）pg/m L vs（5.38±2.11）pg/m L,（7.08±3.62）pg/m L vs（3.86±1.80）pg/m L,（45.77±23.53）U/m L vs（32.50±22.07）U/m L,t=3.591~11.098,P均=0.000],COPD组HP-Ig G阳性患者血清IL-6、IL-17水平及HP-Ig G滴度均高于HP-Ig G阴性患者[（13.16±4.55）pg/m L vs（8.65±4.06）pg/m L,（8.73±3.87）pg/m L vs（6.16±3.41）pg/m L,（52.88±21.39）U/m L vs（13.61±5.78）U/m L,t=3.270~10.208,P=0.000~0.001],HP-Ig G阳性组FEV1、FVC、FEV1/FVC、PCO2、Sa O2均低于HP-Ig G阴性组[（1.24±0.41）L vs（1.49±0.46）L、（2.24±0.51）L vs（2.53±0.48）L,（49.51±5.42）%vs（56.36±6.84）%,（54.27±6.12）mm Hg vs（61.18±6.09）mm Hg,（84.27±11.06）%vs（89.64±10.82）%,t=2.327~5.886,P=0.000~0.022],PCO2高于HP-Ig G阴性组[（49.41±5.28）mm Hg vs（47.04±5.13）mm Hg,t=2.156,P=0.033],差异均有统计学意义。结论 HP感染可影响COPD患者呼吸功能,与COPD的进展存在密切联系。
Objective To investigate the relationship between chronic obstructive pulmonary disease（COPD） andHelicobacter pylori（HP） infection. Methods One hundred and ten COPD cases admitted Weixin country Second People＇sHospital from January, 2010 to January, 2014 were selected as COPD group, and 60 healthy persons of for health checkup wereselected as control group. The levels of serum interleukin（IL）-6, IL-17 and HP-Ig G antibody in the cases of both groups weredetected by enzyme- linked immunosorbent assay. The maximum expiratory volume at the first second（FEV1）, forced vitalcapacity（FVC）、FEVl/FVC、oxygen partial pressure（PO2）、CO2partial pressure（PCO2） and blood oxygen saturation（Sa O2）. Ofthe COPD patients were detected. Results The positive rate of HP-Ig G of the COPD group was higher than that of thecontrol group（70.9% vs 46.7%,χ2=9.720,P=0.002）; The level of the serum IL-6, IL-17 and the titer of HP-Ig G of the COPDgroup were higher than those of the control group[（11.75±4.16）pg/m L vs（5.38±2.11） pg/m L,（7.08±3.62） pg/ml vs（3.86±1.80）pg/m L,（45.77±23.53）U/m L vs（32.50±22.07）U/m L,t =3.591~11.098,P=0.000], the levels of serum IL-6, IL-17 and thetiter of HP-Ig G of the HP-Ig G positive patients of the COPD group were higher than those of the HP-Ig G negative patients[（13.16±4.55）pg/mlvs（8.65±4.06） pg/m L,（8.73±3.87） pg/m L vs（6.16±3.41）pg/m L,（52.88±21.39）U/m L vs（13.61±5.78）U/m L,t =3.270~10.208,P=0.000~0.001],FEV1、FVC、FEV1/ FVC、PO2、Sa O2 of the positive group of HP-Ig G were lower thanthose of the negative group of HP-Ig G [（1.24±0.41）L vs（1.49±0.46）、（2.24±0.51）L vs（2.53±0.48）L,（49.51±5.42）% vs（56.36±6.84）%,（54.27±6.12）mm Hgvs（61.18±6.09）mm Hg,（84.27±11.06）%vs（89.64±10.82）%,t =2.327~5.886,P=0.000~0.022],and PCO2 was higher than that of the negative group of HP-Ig G [（49.41±5.28）mm Hg vs（47.04±5.13）mm Hg,t =2.156,P=0.033],the differences were sta
出处
《中国热带医学》
CAS
2015年第2期213-215,共3页
China Tropical Medicine
关键词
慢性阻塞性肺疾病
幽门螺杆菌
感染
Chronic obstructive pulmonary disease
Helicobacter pylori
Infection
