摘要
目的了解COPD全身炎症表型合并幽门螺杆菌（Hp）感染的临床特点。方法将2014年11月至2016年10月期间诊断的全身炎症表型COPD患者按14C-尿素呼气试验（14C-UBT）结果分为两组，对两组间的一般资料进行比较分析。结果共纳入233例患者，其中132例14C-UBT阳性，感染率56．7％；阳性组身体质量指数（BMI）、FEVl％pre、PaO2及社会支持量表（SSRS）评分低于阴性组，且更倾向于使用非吸入糖皮质激素，差异有统计学意义（P〈0．05）；BMI、FEV，％pred、PaO2、SSRS评分转换成分类变量后，阳性组低BMI者、低FEV，％pred者、I型呼吸衰竭者、低SSRS评分例数多于阴性组，差异均有统计学意义（P〈0．05）。相关分析发现，14C-UBT结果与FEV，％pred、Pa02变化存在低度相关性（｜r｜〉0．3）；将FEV1％pred按GOLD标准分级后，结果与糖皮质激素的使用情况存在低度相关性（｜r｜〉0．3）；糖皮质激素的使用情况与呼吸困难程度存在低度相关性（1rI〉0．3）。FEV1％pred分级、I型呼吸衰竭情况和SSRS评分分级三个变量进入二分类logistic回归模型，FEV1％pred分级OR值〉1，其余两个变量OR值均〈1。结论全身炎症表型COPD患者Hp的感染率与普通人群相仿；存在I型呼吸衰竭和社会支持度低的全身炎症表型COPD群体可能容易合并Hp感染，而良好的FEV，％pred可能有助于减少两者的并存率。
Objective To investigate the clinical features of chronic obstructive pulmonary disease （COPD） complicated with Helicobacter pylori （Hp） infection. Methods During the period from November 2014 to October 2016 with chronic obstructive pulmonary disease who were the diagnosis of systemic inflammatory phenotype were divided into two groups by14 C-urea breath test （14 C-UBT）, to compare and analyze the general information between the two groups. Results 132 cases were positive in all of 233 patients who were enrolled in this study. The infection rate was 56.7 %. The positive group were lower than the negative group in body mass index （BMI）, FEV1% pred, arterial oxygen pressure （PaO2） and social support scale （SSRS） score. And it was more prone to non-use of inhaled corticosteroids, the difference was statistically significant （ P 〈0.05）. The comparisons of categorical variables which the BMI, FEV1%pred, PaO2, SSRS score were converted into were found that there were more patients with tow BMI, bad FEV1% pred, type I respiratory failure and low SSRS score in positive group than in negative group, The differences were statistically significant （ P 〈 0.05）. Correlation analysis showed that the results C-UBT was low correlation with FEV1% pred and PaO2 （ ｜ r ｜〉0.3）. There was low correlation between the usage of glucocorticoids and FEV1 /00 pred which was graded by GOLD standard, also betweenthe usage of glucocorticoid and the degree of dyspnea（ IriS0- 3）. The two classification logistic regression showed that FEV1% pred classification, type I respiratory failure and SSRS score were included in the regression model. The OR value of FEV1%pred was〉 1, while the other two were〈 1. Conclusions The Hp infection rate was not low in patients with systemic inflammatory phenotype of COPD. Patients with systemic inflammatory phenotype of COPD may be prone to Hp infection due to the presence of type I respiratory failure or low social support. And better FEV1 %pred may help red
作者
方桂桔
焦维克
郑秀金
李树奇
薛青
Fang Guiju Jiao Weike Zheng Xiujin Li Shuqi Xue Qing(Department of Respiratory Medicine, Ningde Municipal Hospital Affiliated to Fujian Medical University, Ningde 352100, China)
出处
《国际呼吸杂志》
2017年第20期1535-1540,共6页
International Journal of Respiration
基金
福建省宁德市科技局资助立项项目（20150145）
关键词
肺疾病
慢性阻塞性
全身炎症表型
幽门螺杆菌感染
临床特点
Obstructive pulmonary disease, chronic
Systemic inflammatory phenotype
Helicobacter pylori in{eetion
Clinical {eatures
