摘要
目的:探讨双水平气道正压(BiPAP)无创通气急诊治疗对于重度哮喘患者肺功能的影响。方法:选取2013-01-2016-03在我院急诊治疗的重度哮喘患者100例,随机分为观察组(n=54)和对照组(n=46),对照组给予常规治疗,观察组在对照组基础上加用BiPAP治疗,观察2组治疗前后肺功能以及细胞因子。结果:观察组喘息症状和肺部哮鸣音消失时间分别为(4.10±1.32)d和(3.82±1.15)d,均明显短于对照组(P<0.05);观察组治疗后1s用力呼气量(FEV1)、用力呼气量占用力肺活量比值(FEV1/FVC)和最大呼气量(PEF)分别为(2.25±0.61)L、(70.82±6.38)%和(5.10±1.05)L/S,明显高于对照组(P<0.05);观察组治疗后白细胞介素-4(IL-4)、IL-5、IL-13和干扰素-γ(IFN-γ)分别为(152.21±50.12)ng/L、(140.03±25.11)ng/L、(13.27±1.05)ng/L和(533.02±75.13)ng/L,明显低于对照组(P<0.05)。结论:BiPAP无创通气急诊治疗能有效改善重度哮喘患者肺功能,降低相关血清细胞因子水平。
Objective：To investigate the effect of noninvasive ventilation with bi level positive airway pressure（BiPAP）on pulmonary function in patients with severe asthma.Method：Selected 100 patients with severe asthma who were treated in our hospital from January 2013 to March 2016,randomly divided into observation group（n=54）and control group（n=46）,the control group was given conventional treatment,the observation group was treated with BiPAP on the basis of the control group,observed two groups pulmonary function and cytokine before and after treatment.Result：The observation group panting symptom and wheezing disappearance time were（4.10±1.32）d and（3.82±1.15）d,were significantly shorter than the control group（P〈0.05）;The observation group after treatment1 sforced expiratory volume（FEV1）,1sforced expiratory volume accounted for FVC ratio（FEV1/FVC）and peakexpiratory flow（PEF）were（2.25±0.61）L,（70.82±6.38）% and（5.10±1.05）L/S,significantly higher than the control group（P〈0.05）;The observation group after treatment interleukin 4（IL-4）,IL-5,IL-13 and interferon（IFN-γ）respectively（152.21±50.12）,ng/L（140.03±25.11）,ng/L（13.27±1.05）ng/L and（533.02±75.13）ng/L,significantly lower than the control group（P〈0.05）.Conclusion：BiPAP non-invasive ventilation emergency treatment can effectively improve the pulmonary function of patients with severe asthma,and reduce the level of serum cytokines.
出处
《临床急诊杂志》
CAS
2017年第1期48-50,54,共4页
Journal of Clinical Emergency
关键词
BIPAP无创通气
重度哮喘
急诊治疗
肺功能
细胞因子
BiPAP noninvasive ventilation
severe asthma
emergency treatment
pulmonary function
cytokine
