摘要
目的评价口服联合外涂普萘洛尔治疗婴幼儿血管瘤的临床疗效。方法回顾性分析南京军区福州总医院普通外科2011年6月-2013年12月收治的61例婴幼儿血管瘤患者的临床资料，给予口服联合外涂普萘洛尔治疗，观察其瘤体大小、颜色、质地变化，检测瘤体血流阻力、血流峰值变化，检测血药浓度及不良反应。结果59例获长期随访，按Achauer分级标准评定疗效：有效率为96．61％（57／59），随着用药时间延长，血管瘤瘤体静脉阻力系数增大，血流峰值减小（P〈0．05），用药1、3、5、7个月的血药浓度分另0（166．94±40．75）n∥mL、（164．74±42．31）ng／mL、（152．38±47．49）ng／mL、（174．51±56．67）ng／mL，差异无统计学意义（P〉0．05）。结论口服联合外涂普萘洛尔治疗婴幼儿血管瘤具有疗效显著、不良反应小的优势。
Objective To evaluate the efficacy and security of infantile hemangiomas treatment with oraling propranolol tablets and coating propranolol gel. Methods Study the clinical features and data for 61 infants with hemangiomas who treatment with oral propranolol tablets and coated with of Propranolol gel from June 2011 to December 2013, changes in hemangioma size,texture, color, plasma concentration, tumor peak systolic velocity and resistant index were recorded. Results The results were evaluated using Achauer system ： the total effective rate was 96.61% （57/59）. Resistant index increased but Peak Systolic velocity decreased with treatment for a time （P 〈 0.05 ） , the Plasma concentration is （ 166.94± 40.75 ） ng/mL, （ 164.74±42.31 ） ng/mL, （ 152.38 ± 47.49 ） ng/mL, （174.51± 56.67） ng/mL after treatment 1, 3, 5, 7 month, the difference was not statistically significant （ P 〉 0.05 ）. Conclusions Oral propranolol tablets and coated with of Propranolol gel is an effective treatment for infantile hemangiomas.
出处
《国际外科学杂志》
2015年第3期182-186,F0003,共6页
International Journal of Surgery
基金
福建省科技厅社会发展重点项目（No.2011Y0042）
