摘要
婴幼儿血管瘤(IH)是一种以血管内皮细胞异常增生与血管形成为主要特征的良性肿瘤,其具体发病机制至今仍不明确。近年来长链非编码RNA被证实在IH组织中存在特异性表达,作为促进因子或抑制因子参与血管瘤疾病的发生发展过程。本文就长链非编码RNA作为竞争性内源RNA(ceRNA)形式参与IH发生发展的作用机制作一综述,为未来IH的精准化治疗提供新的研究思路。
Infantile hemangioma(IH)is a benign tumor characterized by abnormal proliferation of vascular endothelial cells and angiogenesis,and its specific pathogenesis is still unclear.In recent years,long non-coding RNAs have been shown to be expressed explicitly in IH tissues and involved in developing hemangioma disease as promoters or inhibitors.This article reviews the mechanism of long-chain non-coding RNA as ceRNA in the pathogenesis and development of IH,which provides new research ideas for the precise treatment of IH in the future.
作者
黄军杰
王烈
赵虎
夏印
张再重
Huang Junjie;Wang Lie;Zhao Hu;Xia Yin;Zhang Zaizhong(Department of General Surgery,900th Hospital of the Joint Logistics Support Force,Fuzhou 350025,China;College of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Department of Vascular Surgery,People's Hospital of Fujian University of Traditional Chinese Medicine/Fujian Provincial People's Hospital,Fuzhou 350004,China)
出处
《中华细胞与干细胞杂志（电子版）》
2022年第6期360-366,共7页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
福建省自然科学基金(2017J01216、2020J011127、2022J01489)。
