摘要
目的:探讨595nm脉冲染料激光联合0.5%马来酸噻吗洛尔滴眼液外敷治疗婴幼儿血管瘤的临床疗效。方法:选取笔者科室2017年6月-2019年1月收治入院的90例婴幼儿血管瘤患儿为研究对象,根据随机数字法将患儿分为观察组和对照组,每组45例。对照组:患儿给予0.5%马来酸噻吗洛尔滴眼液外敷治疗;观察组:给予0.5%马来酸噻吗洛尔滴眼液外敷联合595nm脉冲染料激光治疗。比较两组患儿治疗后的临床疗效,病灶厚度、颜色、面积消退程度,显效时间及不良反应情况。结果:治疗后,观察组患儿的总有效率88.89%,明显高于对照组(68.89%)(χ^2=4.27,P=0.04);观察组患儿显效时间明显早于对照组(P<0.05);观察组患者病灶厚度、颜色、面积消退程度评分明显高于对照组,观察组患儿的不良反应事件总发生率(2.22%)明显低于对照组(15.56%)(χ^2=4.49,P=0.03)。结论:595nm脉冲染料激光联合0.5%马来酸噻吗洛尔滴眼液外敷治疗婴幼儿血管瘤临床疗效显著,见效时间快且不良反应发生率相对较低,外观美容效果明显,值得在临床上推广。
Objective To explore the clinical efficacy of 595 nm pulsed dye laser combined with 0.5% timolol maleate eye drops in the treatment of infantile hemangioma. Methods Ninety infants with hemangioma admitted to our hospital from June 2017 to January 2019 were selected as the study subjects. According to the random number method, the patients were divided into observation group and control group, 45 cases in each group. The control group was treated with 0.5% timolol maleate eye drops, while the observation group was treated with 0.5% timolol maleate eye drops combined with 595 nm pulsed dye laser. The clinical efficacy, effective time and adverse reactions of the two groups after treatment were compared. Results After treatment, the total effective rate of the observation group(88.89%) was significantly higher than that of the control group(68.89%)(χ^2=4.27, P =0.04).The effective time of the observation group was significantly earlier than the control group(P <0.05). The scores of lesion thickness, color and area in the observation group were significantly higher than those in the control group. The incidence of adverse reaction events in the observation group(2.22%) was significantly lower than that in the control group(15.56%)(χ^2=4.49, P=0.03). Conclusion 595 nm pulsed dye laser combined with 0.5% timol maleate eye drops for external application in the treatment of infantile hemangioma has significant clinical efficacy, quick response time and relatively low incidence of adverse reactions, which is worthy of clinical promotion.
作者
陈业莉
王燕
CHEN Ye-li;WANG Yan(Department of Dermatology,Hainan Maternal and Child Health Hospital,Haikou 570000,Hainan,China)
出处
《中国美容医学》
CAS
2020年第3期45-48,共4页
Chinese Journal of Aesthetic Medicine
基金
海南省自然科学基金(编号:818MS170)。
