摘要
目的探索冠心病患者腹型肥胖与高敏C反应蛋白(hs-CRP)和组织基质金属蛋白酶抑制物-1(TIMP-1)之间的关系。方法 85名研究对象分为稳定型冠心病组和健康对照组,均测量身高、体质量、腰围、臀围,同时计算体质指数和腰臀比;进行双能X线吸收法扫描,记录全身及腰部、臀部的脂肪含量,计算全身脂肪比例、腰臀部脂肪比。于空腹状态进行血脂指标及hs-CRP、TIMP-1检测。分析两组间hs-CRP和TIMP-1差异,hs-CRP和TIMP-1与体脂、血脂的相关性。结果冠心病组hs-CRP[(3.41±3.73)mg/L]高于健康对照组[(1.48±1.28)mg/L](P<0.01),TIMP-1值比较[(46.32±17.86)mg/L比(51.39±16.50)mg/L]差异无统计学意义(P=0.21)。冠心病组及健康对照组hs-CRP与WC、BMI、WHR、A/G均有正相关性(均为P<0.05),两组TIMP-1与体脂测量指标、血脂指标、hs-CRP均无相关性(均为P>0.05)。结论 hs-CRP随着体脂含量及腹内脂肪含量增加而增加,提示肥胖是一种慢性低度炎症反应状态,而TIMP-1与腹内脂肪含量增加没有相关性。
Objective To investigate the relationship between intra-abdominal obesity and the serum levels of inflammatory factors- high sensitive C-reactive protein （ hs-CRP） and tissue inhibitor of metalloproteinase-1（TIMP-1） in patients with coronary heart disease （ CHD） . Methods A total of 85 persons were divided into two groups, CHD group and control group. The height, body weight, waist circumference （WC）, body mass index （ BMI） and waist-to-hip ratio（ WHR） were recorded and blood fasting total cholesterol （ TC）, triglyceride （ TG）, high density lipoprotein cholesterol （ HDL-C）, low density lipoprotein cholesterol （LDL-C）, high sensitive C-reactive protein （hs-CRP） and tissue inhibitor of metalloproteinase-1 （TIMP-1） were measured for all subjects. All subjects were evaluated with a DEXA total body scan performed using a Lunar Prodigy system （ GE Healthcare） . The body fat composition and distribution,serum levels of inflammatory factors were also analyzed. Results The level of hs-CRP was significantly higher in CHD group than in control group [（3. 41 ± 3. 73） mg/ L vs. （1. 48 ± 1. 28） mg/ L,＆amp;nbsp;P 〈 0. 01]. The level of TIMP-1 had no significant deviation between the two groups [（46. 32 ±17. 86） mg/ L vs. （51. 39 ± 16. 50）mg/ L, P = 0. 21]. In both groups, hs-CRP had positive correlation with WC,BMI, WHR and A/ G（all P 〈 0. 05）, the level of TIMP-1 was not significantly correlated with BMI, WC, WHR, TF% , A/ G, LDL-C and hs-CRP（all P 〉 0. 05）. Conclusions The accumulation of abdominal adipose tissue is closely correlated to higher hs-CRP. An extent of chronic inflammatory stress might exist in obese person. The level of hs-CRP is significantly increased in CHD patients. However,there is no significantly correlation between serum TIMP-1 and the accumulation of abdominal adipose tissue.
出处
《中国心血管杂志》
2015年第2期110-113,共4页
Chinese Journal of Cardiovascular Medicine
基金
北京市保健专项基金(京06-03号)~~
