摘要
目的观察不同类型冠心病病人血清基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、组织基质金属蛋白酶抑制物-1(tissue-inhibitor of metalloproteinase-1,TIMP-1)和血管紧张素Ⅱ(anginotensinⅡ, AngⅡ)的血清浓度及相关关系,探讨急性冠状动脉综合征发病机制。方法冠心病病人分为急性心肌梗死组、不稳定心绞痛组(上述两组合称急性冠状动脉综合征组)和稳定心绞痛组,每组病人30例,另设健康对照组30例,比较各组间血清MMP-9、TIMP-1、MMP-9/TIMP-1和AngⅡ水平。结果急性心肌梗死组和不稳定心绞痛组血清MMP-9、MMP-9/TIMP-1和AngⅡ水平高于对照组,差异有统计学意义(P<0.01),但稳定心绞痛组血清MMP-9、TIMP-1、MMP-9/TIMP-1和AngⅡ水平与对照组比较差异无统计学意义(P> 0.05),急性冠状动脉综合征组病人血清MMP-9、MMP-9/TIMP-1与AngⅡ水平呈正相关(P<0.01)。结论血清MMP-9、MMP-9/TIMP-1和AngⅡ水平的增高与急性冠状动脉综合征相关,可作为评价冠状动脉粥样硬化斑块稳定性与病变严重程度的一个参考指标。
Objectives To evaluate the association of the peripheral levels of matrix metalloproteinase -9 (MMP-9)/ tissue-inhibitor of metaUoproteinase-1(TIMP-1) and angiotensin Ⅱ (AngⅡ) in patients with different types of coronary heart disease, and to explore the pathogencsis of acute coronary syndromes (ACS). Methods For measuring the serum concentrations of MMP-9, TIMP-1 and Ang Ⅱ, three groups (30 patients per group) with acute myocardial infarction (AMI), unstable angina pectoris (UAP) and stable agina pectoris (SAP) respectively, and one equivalent group (30 healthy volunteers as control group)were recruited. Results ①The serum levels of MMP-9, MMP-9/TIMP-1 and AngⅡ in the patients with ACS were significantly higher than those in the control group (P〈0.01); ②Compared with control group, the levels of MMP-9, TIMP-1, MMP-9/TIMP-1 and AngⅡ in patients with SAP had no significant difference (P〉0.05); ③Significant positive correlation between the serum levels of MMP-9, MMP-9/ TIMP-1 and AngⅡ was observed in the patients with ACS (P 〈 0.01). Conclusions The elevation of serum concentrations of inflammatory markers including MMP-9, MMP-9/TIMP-1 and Ang Ⅱ are associated with initiation and progression of ACS, and they may help predict cardiovascular events.
出处
《岭南心血管病杂志》
2006年第1期10-13,共4页
South China Journal of Cardiovascular Diseases