摘要
目的:通过观察和胃降逆法对反流性食管炎患者食管黏膜环氧合酶-2(COX-2)、E-钙黏蛋白(E-cadherin)表达的影响,探讨和胃降逆法治疗反流性食管炎的作用机理。方法:选择120例反流性食管炎患者,分为中药治疗组、西药治疗组;中药治疗组以和胃降逆法治疗,选用和胃降逆方口服;西药治疗组以奥美拉唑胶囊治疗;治疗8周。患者治疗前后均行胃镜检查及食管黏膜病理活检,免疫组化法测定食管黏膜COX-2、E-cadherin的表达。结果:和胃降逆法能明显改善反流性食管炎患者的组织病理学积分,能明显降低反流性食管炎患者食管黏膜组织COX-2的表达、增强黏膜组织E-cadherin表达。结论:降低食管黏膜组织COX-2表达、升高黏膜组织E-cadherin表达是和胃降逆法治疗反流性食管炎的作用机理之一。
Objective： To observe the effects of stomach - regulation and qi - lowering therapy on the ex- pressions of COX - 2 and E - cadherin in esophageal mucosa of patients with reflux esophagitis, and explore the mechanism. Methods ：120 patients with reflux esophagitis were divided into two groups：Chinese medicine group and west medicine group. The Chinese medicine group was treated with the stomach - regulationg and qi - lower- ing therapy,while the west medicine group was treated with omeprazole capsule, they were treated for 8 weeks. All patients had examination of gastroscope and biopsy of esophageal mucosa before and after treatment. To observe the clinical therapeutic effect and esophageal mucosa pathological change and expressions of COX -2 and E - cadherin in esophageal mucosa were assayed by immunohistoehemistry. Results： Stomach - regulating and qi - lowering therapy could ameliorate the pathology change of esophageal mucosa tissue of reflux esophagitis, and sig- nificantly decrease the expression of COX - 2 and increase the expression of E - cadherm in esophageal mucosa of reflux esophagitis. Conclusion： Stomach - regulating and qi - lowering therapy could significantly decrease the expression of COX - 2 and increase the expression of E - cadherin in esophageal mucosa of patients with reflux esophagitis, and it may be one of the mechanisms of treating reflux esophagitis.
出处
《中国中医药科技》
CAS
2015年第2期128-129,163,共3页
Chinese Journal of Traditional Medical Science and Technology
基金
浙江省中医药管理局资助项目(2008CB053
2009CA086)
杭州市卫生局资助项目(2008B0062)
关键词
食管炎
消化性
和胃降逆法
中药(复方)
环氧合酶
E-钙黏蛋白
esophagitis, degestive
stomach - regulating and qi - lowering therapy
Chinese herbs compund
COX - 2
E - cadherin
