摘要
目的:分析血清H-FABP的动态监测在急性颅脑损伤患者病情判断中的应用价值。方法:将2013年5月-2014年5月期间本院收诊的急性颅脑损伤患者按病情严重程度分为轻度组、中度组和重度组,分别纳入26、23、25例,另选择同期健康体检者20例为对照组。比较不同组间血清H-FABP水平变化,并对患者进行随访,比较不同预后患者间(重度残疾、中度残疾、恢复良好)间入院后24 h血清H-FABP水平差异。结果:急性颅脑损伤患者各个时间段血清H-FABP水平均显著高于对照组(P<0.05);轻度组、中度组、重度组三组间血清H-FABP水平历时性变化有显著差异(P<0.05),血清H-FABP水平随着病情的加重而升高。血清H-FABP水平最高点出现在入院后1 d。不同预后的急性颅脑损伤患者入院后24 h血清H-FABP水平存在显著差异,预后越差者血清H-FABP水平越低(P<0.05)。结论:血清H-FABP水平与急性颅脑损伤患者病情呈正相关,对患者预后评估具有指导意义。
Objective：To analyze the value of the application of dynamic monitoring of serum H-FABP in the determination of acute brain injury patient＇s condition.Method：Patients with acute brain injury in our hospital from May 2013 to May 2014 were divided into the mild, moderate group and severe group according to the severity, included 26 cases, 23 cases and 25 cases. Other 30 cases of healthy were chosen as the control group. The changes of serum H-FABP level of different groups were compared, and they were taken for following up. The differences of 24 hours after hospital admission between serum H-FABP level for different prognosis （severe disability, moderate disability, good recovery） were compared.Result：The Serum H-FABP levels of various time periods of the acute brain injury group were significantly higher than the control group（P〈0.05）.The changes of serum H-FABP level among the three groups lasted mild group,moderate group and severe group were with significant differences（P〈0.05）.The serum H-FABP levels increased with the disease worsen. The highest point of serum levels of H-FABP occurred 1 day after admission.The serum H-FABP levels 24 h after hospitalization for acute brain injury patients with different prognosis were with significant differences,the lower of the serum H-FABP level,the worse of the prognosis（P〈0.05）.Conclusion：Serum H-FABP level in patients is positively correlated with the situation of acute brain injury,and it has instructive significance for prognosis.
出处
《中国医学创新》
CAS
2015年第2期30-32,共3页
Medical Innovation of China
基金
2014年佛山市医学类科技攻关项目(201308249)
