摘要
心肌型脂肪酸结合蛋白(heart fatty acid-binding protein,H-FABP)是一种低分子量可溶性蛋白,在心肌细胞胞浆中含量丰富。具有组织特异性,心肌损伤后血浆中H-FABP水平变化有时间规律性,且血浆H-FABP水平与心肌损伤程度成正相关,故H-FABP可作为诊断早期心肌缺血的生化标志物。现就H-FABP的生理化学特性、检测方法及其在心肌损伤诊断中的应用做一综述。
Heart fatty-acid-binding protein（H-FABP） is a low molecular weight cytostolic protein.It is abundant in the myocardium and has high tissue specificity.Concentration of H-FABP changes regularly in serum after myocardial injury,and is positively correlated with the degree of myocardial injury.H-FABP has been used as an early diagnostic biochemical marker of acute myocardial ischemia.The physiochemical nature,detection of H-FABP,and its application in the diagnosis of myocardial injury are reviewed in this article.
出处
《心血管病学进展》
CAS
2011年第2期281-284,共4页
Advances in Cardiovascular Diseases
关键词
心肌型脂肪酸结合蛋白
心肌损伤
heart fatty-acid-binding protein
myocardial injury
