摘要
目的:评价定量检测血清心型脂肪酸结合蛋白(heart type-fatty acid binding protein,H-FABP)对心房颤动患者检测的临床价值。方法:采用酶联免疫吸附试验一步夹心法检测196名健康体检者、196例心房颤动患者的血清H-FABP,同时测定心肌肌钙蛋白I(cardiac troponin I,cTnI)、肌酸激酶同工酶-MB(creatine kinase isoenzyme MB,CK-MB),并作比较。结果:房颤组治疗前、治疗后及对照组的H-FABP值分别为(2.8±1.3)μg/L,(2.3±1.4)μg/L和(1.6±1.1)μg/L;cTnI值分别为(0.26±0.05)μg/L,(0.23±0.06)μg/L和(0.05±0.02)μg/L;CK-MB值分别为(12.8±3.6)U/L,(13.6±3.1)U/L和(12.1±2.7)U/L。血浆H-FABP水平房颤组治疗前、治疗后及与对照组比较,差异均有统计学意义(P<0.05);血浆cTnI水平在房颤治疗前、治疗后比较差异无统计学意义(P>0.05),与对照组比较差异有统计学意义(P<0.05);血浆CK-MB水平房颤组治疗前、治疗后及与对照组比较差异均无统计学意义(P>0.05)。结论:检测血清H-FABP对心房颤动患者有较重要的临床价值。
Objective： To test the value of detection of heart type-fatty acid binding protein（H-FABP） on evaluating the patients with atrial fibrillation.Methods： H-FABP was measured in 196 healthy persons and 196 patients with atrial fibrillation by ELISA one-step sandwich assay,at the same time,creatine kinase isoenzyme-MB（CK-MB）and cardiac troponin I（cTnI） were determined.Results： The value of H-FABP in patients before treatment with atrial fibrillation,patients with atrial fibrillation after treatment,healthy persons were（2.8±1.3） μg/L,（2.3±1.4） μg/L,（1.6±1.1） μg/L;the value of cTnI were（0.26±0.05） μg/L,（0.23±0.06） μg/L,（0.05±0.02） μg/L;and the value of CK-MB were（12.8±3.6） U/L,（13.6±3.1） U/L,（12.1±2.7） U/L.There was significant difference in H-FABP level between patients before treatment,patients after treatment,healthy persons（P〈0.05）.There was no significant difference in cTnI level between patients before treatment and patients after treatment（P〈0.05）.There was significant difference in cTnI level between patients with atrial fibrillation and healthy persons（P〉0.05）.There was no significant difference in CK-MB level between patients before treatment,patients after treatment,healthy persons（P〉0.05）.Conclusion： Serum H-FABP to patients with atrial fibrillation who tested have an important clinical value.
出处
《江苏大学学报（医学版）》
CAS
2012年第1期66-68,72,共4页
Journal of Jiangsu University：Medicine Edition
基金
连云港卫生局资助项目(08042)
关键词
心房颤动
心型脂肪酸结合蛋白
肌酸激酶同工酶
肌钙蛋白
atrial fibrillation
heart type-fatty acid binding protein
creatine kinase isoenzyme
troponin
