摘要
目的探讨血浆心肌脂肪酸结合蛋白(H-FABP)在急性胸痛患者中的诊断价值。方法对93例胸痛发作6 h内的患者,采用夹心ELISA法检测血浆H-FABP水平,其中急性心肌梗死(AMI)32例、不稳定型心绞痛(UAP)24例、稳定型心绞痛(SAP)22例,非心源性胸痛(NCCP)15例,并选69例健康体检者为对照组。结果AMI组的H-FABP水平(78.58±52.2 ng/mL)最高,UAP组(12.57±5.80 ng/mL)次之,差异有统计学意义(P<0.01);SAP组(3.52±2.29 ng/mL)、NCCP组(4.09±4.18 ng/mL)与对照组(3.30±1.56 ng/mL)比较差异无统计学意义(P>0.05)。以16.8 ng/mL作为H-FABP诊断AMI的最佳临界值,其诊断AMI敏感性为84.4%,特异性为91.8%。结论血浆H-FABP水平可作为心肌坏死或损伤的早期判断指标,可为急性胸痛患者的诊断提供依据。
Objective To explore the significance of plasma heart--type fatty acid--binding protein（H--FABP） in the diagnosis of acute chest pain. Methods 93 patients with chest pain at admission within 6 hours after onset were studied, including 32 patients with acute myocardial infarction（AMI）, 24 patients with unstable angina pectoris （UAP）, 22 patients with stable angina pectoris（SAP） and 15 patients with non--cardiac chest pain（NCCP）. 69 healthy volunteers served as control. Plasma levels of H--FABP were measured by sandwich ELISA. Results The mean concentration of H--FABP in AMI group（ 78. 58 ±52. 2 ng/mL） was the highest and that in UAP group （ 12. 57±5. 80 ng/mL） was the second（ P 〈0. 01 ） ; there was no significant difference between SAP group （ 3. 52± 2. 29 ng/mL ）, NCCP group （ 4. 09±4. 18 ng/mL ） and control group.（ 3. 30 ± 1.56 ng/mL, P 〉0. 05）. The diagnostic sensitivity and specificity of H-- FABP for AMI was 84. 38% and 91.8% when the cut off value was 16. 8 ng/mL. Conclusion Plasma H--FABP level can be an early diagnostic marker for myocardial necrosis or damage within early stage,and may be applicable for use in the early diagnosis of acute chest pain.
出处
《中国急救医学》
CAS
CSCD
北大核心
2006年第4期241-243,共3页
Chinese Journal of Critical Care Medicine
基金
湖北省科技攻关项目(No.2002AA301C80)
关键词
心肌脂肪酸结合蛋白
胸痛
急性心肌梗死
Heart--type fatty acid--binding protein（H--FABP）
Chest pain
Acute myocardial infarction（AMI）
